You have sufficient skillset to build what you need. If you want to stick within them, you can go with Flask for Python. You can keep things simple by going "ol

You have sufficient skillset to build what you need. If you want to stick within them, you can go with Flask for Python. You can keep things simple by going "old-school" and rendering most of the UI on the server-side. For more interactive UI on the frontend, you can go with Vue.js for a lightweight framework or stick with pure javascript. As you mentioned the tradeoff is more familiarity with the code. I find that is important to keep things maintainable. For simple crud apps, often pure javascript with server-side rendering is sufficient.