Literally was just thinking the same thing. Maybe if you put a export tag on it so the cell secreted it, but you'd probably run into glycosylation differences (

Literally was just thinking the same thing. Maybe if you put a export tag on it so the cell secreted it, but you'd probably run into glycosylation differences (since these are bacterial proteins naturally) and you'd probably make very little, again because it's a bacterial protein and not one normally made in mammalian cells (like SARS-CoV-2 spike). The approach I would take (just thinking aloud) would be to solve the structure of the tailocin (probably easy by cryoEM since it's highly structured) and work out the business end mechanism then iterate humanizing it while keeping the important bits constant. I guess it boils down to "probably not straight-forward".