2 ms·

The drugs you're talking about are classified NDRIs not SNRIs. Amphetamine is a releasing agent too. Different drugs have different receptor affinities. And t

• The_rationalist 6y ago
  I was incorrect in saying that stimulants are SNRIS, they are NDRIs as you say, however my point still stands. I don't understand the difference between e.g Adderall and Wellbutrin (which is an NDRI antidepressant) Amphetamine is a releasing agent too good point but this additional aspect aside, dextroamphetamine should have the same antidepressant effect as Wellbutrin and I don't think that is the case, for an unknown reason. Different drugs have different receptor affinities. Oh I thought Adderall was non-selective (affecting all receptors) but I might be wrong and that would be a possible explanation! And the different metabolites do too. I don't know what this can imply.
  • pseudalopex 6y ago
    Dextroamphetamine was prescribed for depression before other classes of drugs were invented. And bupropion is prescribed off label for ADHD. Amphetamine has much stronger dopaminergic effects though. No 2 drugs are exactly alike. Their different metabolites also have their own effects.