4 ms·

So this is basically Viloxazine, a drug no longer sold because it was unprofitable as an antidepressant, and now repurposed as a non-stimulant drug for ADHD. I

So this is basically Viloxazine, a drug no longer sold because it was unprofitable as an antidepressant, and now repurposed as a non-stimulant drug for ADHD. It appears to be cardiotoxic, working like a Tricyclic Antidepressant (TCA), yet less so than imipramine. It works by increasing levels of norepinephrine, altering some serotonin transmission, and maybe reducing some neurotransmitter release in the frontal cortex by increasing certain GABA receptors. I wonder how well this drug will work in real life for children with ADHD...time will tell, and psychiatrists will give us their opinion.

WhompingWindows 6y ago
It will most likely be "non inferior" to the standard of care, since that is the bar for new drugs to clear in any disease area. The issue with that designation is the FDA could compare it to stimulants or to the non-stimulant atomextine, which like Viloxazine is a norepinephrine reuptake inhibitor. Atomoxetine was preferentially used in those cases with added anxiety, since it was found to have anxiolytic effects. Stimulants were sometimes not recommended for anxious patients, since they might contribute to anxiety and sleeplessness for some kids.
- hereme888 6y ago
  > Stimulants were sometimes not recommended for anxious patients, since they might contribute to anxiety and sleeplessness for some kids. Interestingly, Ritalin at low doses is being used at night to help ADD people sleep better. I think its because it keeps their minds from wandering too much when trying to fall asleep. Stimulants are also used to reduce anxiety in ADD people, but as you say, they may also increase it...double edged sword...guess each person has learn how to use it uniquely.