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Amphetamine stimulants are SNRI too just like some antidepressants such as Wellbutrin. What I do not understand is: they have the same mechanism of action (or a
by The_rationalist 6y ago
Amphetamine stimulants are SNRI too just like some antidepressants such as Wellbutrin.
What I do not understand is: they have the same mechanism of action (or at least the same consequence) but the effect is different, one mostly focus on fixing ADHD symptoms and one mostly focus on depression. What explain such a difference in behavior?
BTW unrelated but simultaneously taking SSRIs with stimulants show great results (but there are few studies) (of course don't overdose if you don't want serotonine syndrome)
- refurb 6y agoAmphetamines cause the release of norepinephrine as a major component of their effect.
- The_rationalist 6y agoYes just like SNRIs antidepressants so what is the difference? (stimulants also are dopamine reuptake inhibitors and low serotonine reuptake inhibitor) And no it does not cause the release of any monoamine, when they are released they can stay longer in the brain before being garbage collected which virtually increase their density. It is an unknown whether delayed this garbage collection cycle accelerate ageing or other side effects.
- refurb 6y agoNo, sympathomimetics like amphetamines cause neurotransmitter release in addition to be reuptake inhibitors.
- The_rationalist 6y agoDoesn't induced neurotransmitter release lead to tolerance up to the point that the benefits 100% cancels out?
- pseudalopex 6y agoThe drugs you're talking about are classified NDRIs not SNRIs. Amphetamine is a releasing agent too. Different drugs have different receptor affinities. And the different metabolites do too.
- The_rationalist 6y agoI was incorrect in saying that stimulants are SNRIS, they are NDRIs as you say, however my point still stands. I don't understand the difference between e.g Adderall and Wellbutrin (which is an NDRI antidepressant) Amphetamine is a releasing agent too good point but this additional aspect aside, dextroamphetamine should have the same antidepressant effect as Wellbutrin and I don't think that is the case, for an unknown reason. Different drugs have different receptor affinities. Oh I thought Adderall was non-selective (affecting all receptors) but I might be wrong and that would be a possible explanation! And the different metabolites do too. I don't know what this can imply.
- pseudalopex 6y agoDextroamphetamine was prescribed for depression before other classes of drugs were invented. And bupropion is prescribed off label for ADHD. Amphetamine has much stronger dopaminergic effects though. No 2 drugs are exactly alike. Their different metabolites also have their own effects.