I've been on Zoloft on and off for the past 10 years, and over the years I've come to notice its not-so-subtle effects. I would start by saying that overall, Z

I've been on Zoloft on and off for the past 10 years, and over the years I've come to notice its not-so-subtle effects. I would start by saying that overall, Zoloft has been a life saver for me. I was living with a debilitating level of OCD which interfered with all aspects of my life - from parenting to work. Personally, I suffered from 2 major side effects: 1. Fatigue/Drowsiness - I started falling asleep everywhere and am tired during most of the afternoon. SSRIs are known to affect the brain's ability to induce REM sleep, which in turn have a negative effect not only on our/my wakefulness but also on memory, cognitive skills and mood. 2. My sexual drive was completely obliterated. I can go for weeks without any sexual experience, which is very unusual for a guy my age. To my frustration, even when I had periods when I took time off the drug, my libido didn't really change and remain low. I did some research online and found out that this phenomenon has a name - PSSD (Post SSRI Sexual Dysfunction).