4 ms·
I always thought nocebo was a belief that the medicine would have not therapeutic effect, which is then borne out in reality. But the amplified side effects dov
by flatline 6y ago
I always thought nocebo was a belief that the medicine would have not therapeutic effect, which is then borne out in reality. But the amplified side effects dovetail with my understanding.
As an anecdotal data point, I'm a redhead with a periodic liver condition and a fast metabolism, and I don't metabolize medications normally. I take an antispasmodic for pain relief in doses that leave some people catatonic and it has little to no negative effects on me, over a decade of use. I've tried low doses of muscle relaxants that leave me reeling drunk for hours. Had two awful experiences on SSRIs, I will never try those again should I ever have the need of an antidepressant. I suspect there are sub-populations of people like me who are statistical outliers.
- wincy 6y agoI don’t remember what the test is, but there’s genetic tests for common medication that show how likely it is to have a weird side effect. I once had a psychotic episode after taking Wellbutrin, despite having no history of psychosis (before or since!) My daughter got a genetic screen and a baseline interaction is a 1, with 10 being way off, I suppose. My daughter got a 9 for Wellbutrin. I assume I gave her that. Something about my chemistry just doesn’t interact with that drug the way other people do.
- teekert 6y agoThere is this: https://www.labqualitydays.fi/en/news/pharmacogenetics-do-you-have-your-dna-passport/ https://www.labqualitydays.fi/en/news/pharmacogenetics-do-yo... just the first thing I found.