4 ms·
To be clear, almost all of these studies showed very small effect sizes. The best therapeutics we have are remdesevir (small but real effect on severity, unclea
by entee 6y ago
To be clear, almost all of these studies showed very small effect sizes. The best therapeutics we have are remdesevir (small but real effect on severity, unclear effect on hospitalization and death), dexamethosone (moderate to large effect on death when hospitalized), and antibody drugs for which Lilly’s has already been remove because ineffective against variants though Regeneron’s cocktail seems quite good. Fluvoxamine is I’m sure under investigation, we’ll get a readout eventually but that’s a relatively new result.
The best drugs we have are either:
1.) treat the virus with a novel entity (Regeneron, the other antibodies)
2.) treat the inflammation (dexamethosone, possibly eventually fluvoxamine)
The repurposing and general antivirals (including remdesevir) have little effect and likely won’t make a difference. There are novel drugs being developed (Pfizer just started a protease inhibitor trial) but that’s the only place I’d expect to see real impact, with fluvoxamine as a treat the symptoms wildcard. People have been trying to find drugs or repurpose, and academic medical centers have been working on it. It’s that almost nothing works when subjected to the hard trials.
- maxerickson 6y agoThere's likely room to pick better monoclonal antibodies to use. There was an antibody identified that smashed variants, for instance. https://www.medrxiv.org/content/10.1101/2021.01.26.21250224v2 https://www.medrxiv.org/content/10.1101/2021.01.26.21250224v... Some contextualization at https://twitter.com/K_G_Andersen/status/1367592606641704961 https://twitter.com/K_G_Andersen/status/1367592606641704961
- nerdponx 6y agoIs the Regeneron drug an example of the "monoclonal antibodies" that I keep hearing about?
- entee 6y agoYes. Monoclonal antibodies are single antibodies that are produced at scale. Regeneron has 2 mABs that they mix to create a cocktail. Your immune system generated a polyclonal antibody response, which is to say it creates a multitude of different antibodies against the virus. If most aren’t great, that’s fine as long as one is good enough. If a few work together to neutralize the virus, that’s also fine. If you can identify one of those antibodies as especially good, you can then clone it and make a bunch of it artificially, hence “monoclonal”.