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What is the effect of taking multiple vaccines, with a few months of gap? Sputnik is available to me starting yesterday. If I take it now, will taking a differe

What is the effect of taking multiple vaccines, with a few months of gap? Sputnik is available to me starting yesterday. If I take it now, will taking a different vaccine that is effective against the variants later on, give me immunity? Or will the new vaccines not do anything because the immune response has already happened?

mensetmanusman 6y ago
No one knows, it hasn’t happened before and it would probably be hard in the past to just test continuous vaccinations indefinitely.
- astrange 6y ago
  Flu shots are taken every year, so we do know the effects of those (it's okay). In this case it depends what kind of vaccine each one is.
raducu 6y ago
The only issue could be if you take Sputnik now and Sputnik V2 too soon, if they use the same viral vector in the future (you could develop antibodies to the adenovirus itself, afik Sputnik uses 2 adenoviruses for dose 1 and dose 2 for this exact reason) if the vector is different, they will both work(in the case of mRNA the vector is not an issue, afik). So if you're allowed to get another vaccine in a couple of months, take Sputnik now.
amluto 6y ago
It’s unknown. There is a phenomenon called “original antigenic sin” that may or may not apply. There’s also a potential issue with immunity to the vector.
kurthr 6y ago
Multiple vaccines have not been tested, but immunology suggests they would be safe (using the same adeno-virus would likely be less effective since your body would pre-empt spike production). One possible hypothesis for why Sputnik (which it self is a succession of two different adeno-virus laden spike protein generators) is less effective is that it (unlike Moderna, Pfizer, J&J) does not appear to use a stabilized Spike protein, which makes the immune response it generates more susceptible to this substitution. They key is what parts of the artificial vaccine spike you develop antibodies for, as to how effective the vaccine is for a variant since much of the active portion of the protein is unchanged. However, since both Moderna and Pfizer are testing mRNA "booster" vaccines specifically for the SA variant, you might just wait for that. They don't have an adeno-virus vector that could be pre-empted by immune response.

mensetmanusman 6y ago

No one knows, it hasn’t happened before and it would probably be hard in the past to just test continuous vaccinations indefinitely.

astrange 6y ago
Flu shots are taken every year, so we do know the effects of those (it's okay). In this case it depends what kind of vaccine each one is.

raducu 6y ago

The only issue could be if you take Sputnik now and Sputnik V2 too soon, if they use the same viral vector in the future (you could develop antibodies to the adenovirus itself, afik Sputnik uses 2 adenoviruses for dose 1 and dose 2 for this exact reason) if the vector is different, they will both work(in the case of mRNA the vector is not an issue, afik). So if you're allowed to get another vaccine in a couple of months, take Sputnik now.

amluto 6y ago

It’s unknown. There is a phenomenon called “original antigenic sin” that may or may not apply. There’s also a potential issue with immunity to the vector.

kurthr 6y ago

Multiple vaccines have not been tested, but immunology suggests they would be safe (using the same adeno-virus would likely be less effective since your body would pre-empt spike production). One possible hypothesis for why Sputnik (which it self is a succession of two different adeno-virus laden spike protein generators) is less effective is that it (unlike Moderna, Pfizer, J&J) does not appear to use a stabilized Spike protein, which makes the immune response it generates more susceptible to this substitution. They key is what parts of the artificial vaccine spike you develop antibodies for, as to how effective the vaccine is for a variant since much of the active portion of the protein is unchanged. However, since both Moderna and Pfizer are testing mRNA "booster" vaccines specifically for the SA variant, you might just wait for that. They don't have an adeno-virus vector that could be pre-empted by immune response.