4 ms·
More commentary on reddit: https://www.reddit.com/r/COVID19/comments/milxvy/qualitatively_distinct_modes_of_sputnik_v/ https://www.reddit.com/r/COVID19/comments
by rediguanayum 6y ago
More commentary on reddit:
https://www.reddit.com/r/COVID19/comments/milxvy/qualitatively_distinct_modes_of_sputnik_v/ https://www.reddit.com/r/COVID19/comments/milxvy/qualitative...
It basically echoes comments here, that there's a significant reduction in neutralization (and paper says several instances of no neutralization in some sera). Comments also says that the pre-fusion spike stabilization used on the mRNA vaccine and J&J (which otherwise similar to Sputnik as both use Adenovirus vector) seems to be the difference.
- kurthr 6y agoIf you're interested in a fairly long discussion with the(?!) guy who developed the stabilized spike protein substitutions. Have a look at this TWiV. https://www.youtube.com/watch?v=P9S28_5AqUA https://www.youtube.com/watch?v=P9S28_5AqUA