Everybody I've talked to who uses tmux has switched away from the default keybindings. I agree on straying away from defaults for most things since using custom

Everybody I've talked to who uses tmux has switched away from the default keybindings. I agree on straying away from defaults for most things since using custom configs makes it more difficult to work on random servers down the line. But.. tmux is an exception to that rule, especially since it only needs to be configured on one host, and none of the servers you might need to ssh into. Spend a couple hours some night editing someone else's public tmux config and it'll really pay off. (FWIW, my capslock has been rebound to be ctrl, and I do ctrl-a as my tmux-mode key. Really recommend if you use a terminal a lot.)