In reality, not that much. There's a pretty detailed benchmark breakdown here [1]. From my experience, the point where you see the different methods start to di

In reality, not that much. There's a pretty detailed benchmark breakdown here [1]. From my experience, the point where you see the different methods start to diverge is past the point you're going to be able to handle on a single box with a real-world application anyway. I find that gunicorn is slightly easier to setup (not requiring Apache to be installed, etc), so I've stuck with it. To each their own! [1] http://nichol.as/benchmark-of-python-web-servers http://nichol.as/benchmark-of-python-web-servers