Acids such as citric acid are also very safe, but definitely not in the context of brushing teeth as they dissolve enamel. There simply isn't enough safety data

Acids such as citric acid are also very safe, but definitely not in the context of brushing teeth as they dissolve enamel. There simply isn't enough safety data _in that context_ for dentists to start recommending EDTA vs regular fluoride toothpaste. In one in vitro study I found, EDTA is shown to cause erosion https://www.medigraphic.com/pdfs/odon/uo-2012/uoi121b.pdf https://www.medigraphic.com/pdfs/odon/uo-2012/uoi121b.pdf so I'd say more studies are required.