5 ms·

Moreover, it's only one shot. J&J is currently enrolling for a 2-shot trial (https://clinicaltrials.gov/ct2/show/NCT04614948 https://clinicaltrials.gov/ct2/show

Moreover, it's only one shot. J&J is currently enrolling for a 2-shot trial (https://clinicaltrials.gov/ct2/show/NCT04614948 https://clinicaltrials.gov/ct2/show/NCT04614948), unfortunately, the control arm .. is no vaccination. I can imagine how this may hinder recruitment.

xeromal 6y ago
I wonder if us legacy J&J users will be able to get a second dose at some point.
- bluGill 6y ago
  That is the plan if it is helpful, but it depends on a lot of factors. First, of course how much better is a second shot vs one - if the difference is minimal it probably isn't worth it. I'm guessing that we will forever say the difference is too minimal - it works well enough with one shot, so why not give the second shot as a first shot to someone else? Of course this gets mixed in those who might be more vulnerable (and thus more helped with a second shot) if we can figure that out. And there is the possibility of buy a second shot for you (at double price but that isn't stated), and we send a free shot to some poor person in [pick a poor country]. There is also the question of do we reach herd immunity - if Covid isn't spreading in your country and you are not traveling to a different country where it is why make your arm sore? Probably more considerations, but the above should get you started thinking of them.
  - xeromal 6y ago
    My interest is purely from avoiding further unpleasantness from catching COVID19. I took the J&J vaccine and ended up around 103F fever for a few hours so I have an inkling if I end up in the 28% who still has symptoms when catching COVID19, would I go through another bout of fevers and chills. Of course I could ride it out, but if I had the opportunity to avoid, I would!
- antattack 6y ago
  First dose of Russian Sputnik V vaccine uses the same adenovirus as J&J vaccine, both of virus vector type. Second dose of Sputnik V is using different adenovirus. I would think J&J second dose would have to use different adenovirus also.
  - bluGill 6y ago
    There has been a lot of speculation on that. It isn't an unreasonable idea. However we don't know if it is true or not. We will have to wait for the 2 dose trials to see how they turn out.

xeromal 6y ago

I wonder if us legacy J&J users will be able to get a second dose at some point.

bluGill 6y ago
That is the plan if it is helpful, but it depends on a lot of factors. First, of course how much better is a second shot vs one - if the difference is minimal it probably isn't worth it. I'm guessing that we will forever say the difference is too minimal - it works well enough with one shot, so why not give the second shot as a first shot to someone else? Of course this gets mixed in those who might be more vulnerable (and thus more helped with a second shot) if we can figure that out. And there is the possibility of buy a second shot for you (at double price but that isn't stated), and we send a free shot to some poor person in [pick a poor country]. There is also the question of do we reach herd immunity - if Covid isn't spreading in your country and you are not traveling to a different country where it is why make your arm sore? Probably more considerations, but the above should get you started thinking of them.
- xeromal 6y ago
  My interest is purely from avoiding further unpleasantness from catching COVID19. I took the J&J vaccine and ended up around 103F fever for a few hours so I have an inkling if I end up in the 28% who still has symptoms when catching COVID19, would I go through another bout of fevers and chills. Of course I could ride it out, but if I had the opportunity to avoid, I would!
antattack 6y ago
First dose of Russian Sputnik V vaccine uses the same adenovirus as J&J vaccine, both of virus vector type. Second dose of Sputnik V is using different adenovirus. I would think J&J second dose would have to use different adenovirus also.
- bluGill 6y ago
  There has been a lot of speculation on that. It isn't an unreasonable idea. However we don't know if it is true or not. We will have to wait for the 2 dose trials to see how they turn out.