3 ms·
As an example, Gleevec has turned CML from a terminal cancer into a chronic, manageable condition for most patients. Life expectancy for CML is nearly the same
by sterlind 6y ago
As an example, Gleevec has turned CML from a terminal cancer into a chronic, manageable condition for most patients. Life expectancy for CML is nearly the same as the general population now. [0]
But Gleevec doesn't work on prostate or breast cancer.
Cancers happen when mutations in a cell cause it to proliferate uncontrollably; the genetic circuits that need to be activated differ by cell type. For instance, prostate cancer can be treated with anti-androgens, since testosterone is required for prostate cells to reproduce. The cancer can evolve to resist anti-androgen therapy by mutating the androgen receptor so it's always stuck on. It's all circuits, and all the circuits are different.
0. https://academic.oup.com/jnci/article/103/7/553/2517175 https://academic.oup.com/jnci/article/103/7/553/2517175