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What do you mean? Like creating every protin without a ribosome? Why would you need to go to that lengths of artfical? Seams to like you have to start from the

What do you mean? Like creating every protin without a ribosome? Why would you need to go to that lengths of artfical? Seams to like you have to start from the top up in one way or another. Starting from the complete bottom just seams over the top.

faeyanpiraat 6y ago
If you can figure out how to go bottom up, it will result in new innovations in microscopic manufacturing methods.
- deleted 6y ago
  [deleted]
- callesgg 6y ago
  Or... you can just use the top up built cell to manufacture things. Why build your own nanorobots when there are pre made nanorobots that already works.
  - faeyanpiraat 6y ago
    Because switching to a different chemical composition (not carbon based) is more likely that way. I think it must be possible to create equvivalent functionality from more durable materials. This certainly is scify, but imagine changing all your cells one by one to cells which can withstand wider temperature ranges, and corrode (rot?) half as easily.
hutzlibu 6y ago
Starting from the bottom means, you really did understand it all, once completed ..
- callesgg 6y ago
  If that is the ultimate purpose and you have a way to slowly progress towards full understanding sure.
  - hutzlibu 6y ago
    Oh, I would say many researchers have that goal, but probably not many would consider it a realistic goal to be achieved in their lifetime .. (all assumed, biology is not my area)
tmabraham 6y ago
> Starting from the complete bottom just seams over the top. Is it really? "What I cannot create, I do not understand." - Richard Feynman And to clarify, currently the ribosomes are provided as part of the cell-free transcription/translation system. Additionally, amino acids, tRNA (plus tRNA synthetase), RNA polymerase, and a primitive energy source (ATP with some extra energy in creatine phosphate) are all provided. Here are the components of the most common cell-free transcription/translation systems (PURE): https://www.nature.com/articles/nprot.2015.082/tables/1 https://www.nature.com/articles/nprot.2015.082/tables/1
laurent92 6y ago
Yes. Starting from the bottom, we might in the process discover that 90%-99% of cell components are cruft/inefficient, and discover how to make cells 10 or 100 times smaller. Imagine being able to inject neurons in the brain that are 100 times smaller.

faeyanpiraat 6y ago

If you can figure out how to go bottom up, it will result in new innovations in microscopic manufacturing methods.

deleted 6y ago
[deleted]
callesgg 6y ago
Or... you can just use the top up built cell to manufacture things. Why build your own nanorobots when there are pre made nanorobots that already works.
- faeyanpiraat 6y ago
  Because switching to a different chemical composition (not carbon based) is more likely that way. I think it must be possible to create equvivalent functionality from more durable materials. This certainly is scify, but imagine changing all your cells one by one to cells which can withstand wider temperature ranges, and corrode (rot?) half as easily.

hutzlibu 6y ago

Starting from the bottom means, you really did understand it all, once completed ..

callesgg 6y ago
If that is the ultimate purpose and you have a way to slowly progress towards full understanding sure.
- hutzlibu 6y ago
  Oh, I would say many researchers have that goal, but probably not many would consider it a realistic goal to be achieved in their lifetime .. (all assumed, biology is not my area)

tmabraham 6y ago

> Starting from the complete bottom just seams over the top. Is it really? "What I cannot create, I do not understand." - Richard Feynman And to clarify, currently the ribosomes are provided as part of the cell-free transcription/translation system. Additionally, amino acids, tRNA (plus tRNA synthetase), RNA polymerase, and a primitive energy source (ATP with some extra energy in creatine phosphate) are all provided. Here are the components of the most common cell-free transcription/translation systems (PURE): https://www.nature.com/articles/nprot.2015.082/tables/1 https://www.nature.com/articles/nprot.2015.082/tables/1

laurent92 6y ago

Yes. Starting from the bottom, we might in the process discover that 90%-99% of cell components are cruft/inefficient, and discover how to make cells 10 or 100 times smaller. Imagine being able to inject neurons in the brain that are 100 times smaller.