3 ms·

https://vizbi.org/Posters/Images/2021/vB26.png https://vizbi.org/Posters/Images/2021/vB26.png They're working towards it :)

by koeng 6y ago

choeger 6y ago
I wonder if this is going to be incredibly useful or totally over the top for research. Imagine a development like the BioNTech vaccine. With an atomic-resolution cell simulator, you could verify your mRNA code, including the delivery into the cell itself and watch it perform. But would that be like watching my CPU decode and fetch instructions, interesting but completely useless for most practical applications, or like a debugger introspecting a running process, an incredible useful tool?
- akiselev 6y ago
  > But would that be like watching my CPU decode and fetch instructions, interesting but completely useless for most practical applications, or like a debugger introspecting a running process, an incredible useful tool? It would be like watching the cloud of electrons moving over transistors across an entire chip, without the benefit of knowing quantum mechanics. Except in this analogy, everyone is in the same boat and working on a single codebase that's the surviving vestige of billions of years of "just good enough" coders fighting it out, so every little bit helps.
- dsign 6y ago
  IMO, an atomic-resolution cell simulator would be extremely useful. If you have an atomic-resolution cell simulator, you can add lots of automatic interpretation to layer up the information. For example, you can use relatively basic inference software to get a list of metabolite interactions (and their rates and derivatives). An additional layer would contain inferences about the way those metabolites move inside the ER and so on. Even with those layers, the amount of brain power needed to understand anything would be significant. We may not have enough experts or expert-years to accomplish much. Perhaps a further step would be to make the models more accessible to people with less specialization. Even find more playful names for cell metabolites, the ones we use right now are utterly unpronounceable.

https://vizbi.org/Posters/Images/2021/vB26.png https://vizbi.org/Posters/Images/2021/vB26.png They're working towards it :)

by koeng 6y ago

https://vizbi.org/Posters/Images/2021/vB26.png https://vizbi.org/Posters/Images/2021/vB26.png They're working towards it :)

choeger 6y ago

I wonder if this is going to be incredibly useful or totally over the top for research. Imagine a development like the BioNTech vaccine. With an atomic-resolution cell simulator, you could verify your mRNA code, including the delivery into the cell itself and watch it perform. But would that be like watching my CPU decode and fetch instructions, interesting but completely useless for most practical applications, or like a debugger introspecting a running process, an incredible useful tool?

akiselev 6y ago
> But would that be like watching my CPU decode and fetch instructions, interesting but completely useless for most practical applications, or like a debugger introspecting a running process, an incredible useful tool? It would be like watching the cloud of electrons moving over transistors across an entire chip, without the benefit of knowing quantum mechanics. Except in this analogy, everyone is in the same boat and working on a single codebase that's the surviving vestige of billions of years of "just good enough" coders fighting it out, so every little bit helps.
dsign 6y ago
IMO, an atomic-resolution cell simulator would be extremely useful. If you have an atomic-resolution cell simulator, you can add lots of automatic interpretation to layer up the information. For example, you can use relatively basic inference software to get a list of metabolite interactions (and their rates and derivatives). An additional layer would contain inferences about the way those metabolites move inside the ER and so on. Even with those layers, the amount of brain power needed to understand anything would be significant. We may not have enough experts or expert-years to accomplish much. Perhaps a further step would be to make the models more accessible to people with less specialization. Even find more playful names for cell metabolites, the ones we use right now are utterly unpronounceable.