6 ms·

What did they botch? Maybe I am uninformed on this, but from my perspective they did everything right - to the best of their abilities.

meepmorp 6y ago
HN is teeming with subject matter experts of all kinds, particularly rapid adenovirus-based vaccine development. Best not to question it.
- listenallyall 6y ago
  and large container ship rescue specialists too.
  - whateveracct 6y ago
    It's crazy that you get to hear theoretical physicists casually mention their personal theories too. HN is quite the zoo!
    - postalrat 6y ago
      Saving the world is a thankless task.
      - meepmorp 6y ago
        You're welcome, bro.
refurb 6y ago
They ran a clinical trial where they accidentally gave a number of patients half a dose. Apparently this was due to lack of validation of an assay by Oxford. I think the problem is that these "small" issues pop up which just further erodes confidence in the vaccine.
- Wildgoose 6y ago
  And yet that accident enabled them to discover that an initial "half" dose eas actually more successful than an initial "full" dose. All of this has been very well scrutinised and documented, far more so than any other vaccine supplier.
  - refurb 6y ago
    It was serendipitous that it happened, but my god, that's not supposed to happen in clinical trials run by companies like AZ.
    - jadavies 6y ago
      I suggest that you don't read up on how penicillin was discovered then!
andreskytt 6y ago
Leaving aside the properties of the vaccine, not keeping promises is a really bad look. Committing to deliver x amount and then delivering .8x without much of an explanation is a sign of bad comms at the very least. And that has not happened once. If you look at how many times AZ has promised to start keeping to the schedule and get their capacity up, the list gets pretty long. It does not take a management genius to predict, that vaccine deliveries in EU are going to be observed using a microscope and that the moment you flinch, they’ll bite. And AZ flinched. We’ve all been there. Engineers tell the leadership x is possible, customer demands 2x, leadership bullies engineers into agreeing to deliver on the impossible and in the end it all goes to hell. And that’s a clear leadership failure.

meepmorp 6y ago

HN is teeming with subject matter experts of all kinds, particularly rapid adenovirus-based vaccine development. Best not to question it.

listenallyall 6y ago
and large container ship rescue specialists too.
- whateveracct 6y ago
  It's crazy that you get to hear theoretical physicists casually mention their personal theories too. HN is quite the zoo!
  - postalrat 6y ago
    Saving the world is a thankless task.
    - meepmorp 6y ago
      You're welcome, bro.

refurb 6y ago

They ran a clinical trial where they accidentally gave a number of patients half a dose. Apparently this was due to lack of validation of an assay by Oxford. I think the problem is that these "small" issues pop up which just further erodes confidence in the vaccine.

Wildgoose 6y ago
And yet that accident enabled them to discover that an initial "half" dose eas actually more successful than an initial "full" dose. All of this has been very well scrutinised and documented, far more so than any other vaccine supplier.
- refurb 6y ago
  It was serendipitous that it happened, but my god, that's not supposed to happen in clinical trials run by companies like AZ.
  - jadavies 6y ago
    I suggest that you don't read up on how penicillin was discovered then!

andreskytt 6y ago

Leaving aside the properties of the vaccine, not keeping promises is a really bad look. Committing to deliver x amount and then delivering .8x without much of an explanation is a sign of bad comms at the very least. And that has not happened once. If you look at how many times AZ has promised to start keeping to the schedule and get their capacity up, the list gets pretty long. It does not take a management genius to predict, that vaccine deliveries in EU are going to be observed using a microscope and that the moment you flinch, they’ll bite. And AZ flinched. We’ve all been there. Engineers tell the leadership x is possible, customer demands 2x, leadership bullies engineers into agreeing to deliver on the impossible and in the end it all goes to hell. And that’s a clear leadership failure.