One issue with Pawpaw is that some varieties have high levels of acetogenins: https://en.wikipedia.org/wiki/Annonacin https://en.wikipedia.org/wiki/Annonacin

One issue with Pawpaw is that some varieties have high levels of acetogenins: https://en.wikipedia.org/wiki/Annonacin https://en.wikipedia.org/wiki/Annonacin https://en.wikipedia.org/wiki/Acetogenin https://en.wikipedia.org/wiki/Acetogenin There are some low annonacin varieties: Sunflower, Wabash, Potomac, Zimmerman, and Wells.