3 ms·
Why do they need to refrigerate COVID mRNA vaccines? Because the mean lifetime of mRNA is 5 minutes (at body temperature). Arrhenius acceleration (or decelera
by xyzzy21 6y ago
Why do they need to refrigerate COVID mRNA vaccines?
Because the mean lifetime of mRNA is 5 minutes (at body temperature).
Arrhenius acceleration (or deceleration) with cold temperatures is the only viable trick. But even then, it's going to disappear quickly once it hits a target cell and the liposome is absorbed. Probably not a great half-life even then.
https://bionumbers.hms.harvard.edu/bionumber.aspx?id=108592&ver=4&trm=lifetime&org= https://bionumbers.hms.harvard.edu/bionumber.aspx?id=108592&...
- tmearnest 6y agoNo this is due to degradation from nucleases. In fact the number you linked is specific to bacteria. Lifetime of mRNA in eukaryotes is on the order of hours, and this is due to active degradation as well.