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Just collect data on the rate of infections of the members of the households of those in the study. Run an IV regression on the results. Since a significant fra
by dcolkitt 6y ago
Just collect data on the rate of infections of the members of the households of those in the study. Run an IV regression on the results. Since a significant fraction of transmission comes from those sharing a household, protection against asymptomatic transmission will show up in lower household infection rate among the vaccinated group.
- maxerickson 6y agoPreventing severe infection is a fine endpoint though. A vaccine or treatment that does that is a minimum viable tool for moving forward. Reduces deaths, reduces utilization of medical resources, etc, and then when it's a vaccine, it's pretty likely that it also reduces transmission. But it doesn't need to reduce transmission to be worth an awful lot.
- amluto 6y agoThis isn’t about whether to approve or use the vaccine. It’s about how to plan the public health response around the vaccine.