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Does anyone have any insights as to why it seems like AZ has mismanaged everything from the start?

by SamBam 6y ago

kmlx 6y ago
the only guess going around is that they're not a traditional vaccine manufacturer. as such, they don't have the expertise for this kind of a roll out. but this is still a guess at this point.
- SamBam 6y ago
  I was wondering that, but they seem to be a more mature company than Moderna, and have more experience with bringing out products in general. Did Moderna get more support from other companies/the government?
  - mrep 6y ago
    Moderna got 955 million for investment of their vaccine back in May, and an additional 1.53 billion back in August for the purchase of 100 million doses which has also further been increased to 300 million doses now: https://www.cnbc.com/2020/08/14/the-us-has-already-invested-billions-on-potential-coronavirus-vaccines-heres-where-the-deals-stand.html https://www.cnbc.com/2020/08/14/the-us-has-already-invested-...
    - SamBam 6y ago
      And I guess the unstated conclusion is that they wisely spent a chunk of that money on hiring people with a long history of FDA compliance, regulatory guidelines, international export regulations, and product management? (I suppose my point is that I would have expected such teething problems from a young company like Moderna, but they seem to have done everything right.)
      - mrep 6y ago
        Yes, that money came from the US government program literally codenamed "Operation Warp Speed" which was set up as a public–private partnership initiated by the United States government to facilitate and accelerate the development, manufacturing, and distribution of COVID-19 vaccines, therapeutics, and diagnostics: https://en.wikipedia.org/wiki/Operation_Warp_Speed https://en.wikipedia.org/wiki/Operation_Warp_Speed
throwaway19937 6y ago
There's plenty of blame to go around. The EU started negotiating later and signed a contract with fewer remedies than the UK (https://www.politico.eu/article/the-key-differences-between-the-eu-and-uk-astrazeneca-contracts/ https://www.politico.eu/article/the-key-differences-between-...). It's not at all surprising that AZ is focusing their efforts on the UK.
- SiempreViernes 6y ago
  Right, the contract with the EU alone explains why they fail to meet their commitments, have trouble with the manufacturing plant, screw up the dosing in the trials, and don't promptly provide proper paperwork to authorities during at basically all stages of the process. Must have been some contract...

Does anyone have any insights as to why it seems like AZ has mismanaged everything from the start?

by SamBam 6y ago

Does anyone have any insights as to why it seems like AZ has mismanaged everything from the start?

kmlx 6y ago

the only guess going around is that they're not a traditional vaccine manufacturer. as such, they don't have the expertise for this kind of a roll out. but this is still a guess at this point.

SamBam 6y ago
I was wondering that, but they seem to be a more mature company than Moderna, and have more experience with bringing out products in general. Did Moderna get more support from other companies/the government?
- mrep 6y ago
  Moderna got 955 million for investment of their vaccine back in May, and an additional 1.53 billion back in August for the purchase of 100 million doses which has also further been increased to 300 million doses now: https://www.cnbc.com/2020/08/14/the-us-has-already-invested-billions-on-potential-coronavirus-vaccines-heres-where-the-deals-stand.html https://www.cnbc.com/2020/08/14/the-us-has-already-invested-...
  - SamBam 6y ago
    And I guess the unstated conclusion is that they wisely spent a chunk of that money on hiring people with a long history of FDA compliance, regulatory guidelines, international export regulations, and product management? (I suppose my point is that I would have expected such teething problems from a young company like Moderna, but they seem to have done everything right.)
    - mrep 6y ago
      Yes, that money came from the US government program literally codenamed "Operation Warp Speed" which was set up as a public–private partnership initiated by the United States government to facilitate and accelerate the development, manufacturing, and distribution of COVID-19 vaccines, therapeutics, and diagnostics: https://en.wikipedia.org/wiki/Operation_Warp_Speed https://en.wikipedia.org/wiki/Operation_Warp_Speed

throwaway19937 6y ago

There's plenty of blame to go around. The EU started negotiating later and signed a contract with fewer remedies than the UK (https://www.politico.eu/article/the-key-differences-between-the-eu-and-uk-astrazeneca-contracts/ https://www.politico.eu/article/the-key-differences-between-...). It's not at all surprising that AZ is focusing their efforts on the UK.

SiempreViernes 6y ago
Right, the contract with the EU alone explains why they fail to meet their commitments, have trouble with the manufacturing plant, screw up the dosing in the trials, and don't promptly provide proper paperwork to authorities during at basically all stages of the process. Must have been some contract...