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Overselling their production capacity by a lot, for one. The major protocol violations in their trials and the weird way they are handling it, are another.
by markus92 6y ago
Overselling their production capacity by a lot, for one. The major protocol violations in their trials and the weird way they are handling it, are another.
- krona 6y agoThere was no production capacity 12 months ago. EU suppliers failed to upgrade and improve yields sufficiently in time. The UK/US started expanding right at the start of the pandemic, so effectively had a 6-8 month head start.
- markus92 6y agoEasy to say but not necessarily true. Let's look at the Halix factory, which is the main point of contention in the EU/UK dispute. The Dutch government (thus, EU) already offered them a major contract in March/April '20, for precisely this purpose. They already had started expanding in Feb '20 as part of their production for the AZ trial, so they declined.
- sampo 6y ago> Overselling their production capacity by a lot, for one. They grow live virus in live cell cultures. Scaling bioreactors from 50 liter test reactors to 1000 or 2000 liter production size reactors can be tricky. Even when everything goes well, bioreactors can have 3-fold differences in yield. I would assume either AZ quoted the ideal production capacity. Or maybe AZ quoted a range, and EU politicians took the maximum of the range and believed that would be achievable.
- yread 6y ago> Scaling bioreactors from 50 liter test reactors to 1000 or 2000 liter production size reactors can be tricky Yes, especially if you've never done vaccine production before!