5 ms·

The fact that they didn't find an intermediate host after more than a year of search should tell you something.

ajross 6y ago
It tells you that that kind of analysis is extraordinarily difficult. How many documented three+ species viral evolution paths can you cite from the literature?
freeflight 6y ago
It took nearly a century to somewhat establish the geographical origin of the Spanish flu and even these results are still a bit controversial to this day [0]. The reality is that epidemiology is not a straight forward nor simple field of research, finding concrete and solid answers is usually way more difficult than most people assume when they want answers to point fingers. [0] https://academic.oup.com/emph/article/2019/1/18/5298310 https://academic.oup.com/emph/article/2019/1/18/5298310
- gabaix 6y ago
  Find and concrete answers is especially hard when the investigated actively hides and deflects.
- bgandrew 6y ago
  what I'm saying is that until the closest relative to SARS-CoV-2 is known to be exactly the same virus that was researched in Wuhan institute of virology, it's obvious that lab leak should be number 1 hypothesis. That wouldn't be so, if covid started in Beijing or Nanjing. Or if Wuhan wouldn't be home to one of the two BSL–4 labs in China. And the only lab to my mind that investigated SARS-CoV-2 closest known relative before the outbreak. But since all those facts are true, I really have a hard time considering other hypotheses.
  - Uberphallus 6y ago
    SARS-CoV-2 was first detected in Wuhan, but it's not that clear that it's where it originated. The genetic divergence between RaTG13 and SARS-CoV-2 is explained with about 20 years of natural evolution, which puts the common ancestor somewhere in late 2000s, and given that bats migrate, the ancestor occurred potentially anywhere in Eurasia or even Africa. Post-hoc analysis of waste water and patient samples in Europe shows that it was circulating in Europe by mid-late 2019, way before the patient 0 in Wuhan. So the leak hypothesis, while feasible, would have to address why the virus was seemingly abroad before it became a problem in Wuhan itself. Of course it's a reasonable hypothesis, but putting it as number 1 is kind of reframing the whole picture.
    - bgandrew 6y ago
      "Post-hoc analysis of waste water and patient samples in Europe shows that it was circulating in Europe by mid-late 2019, way before the patient 0 in Wuhan." now this is what's called a conspiracy theory.
      - 2-tpg 6y ago
        > ROME (Reuters) - The new coronavirus was circulating in Italy in September 2019, a study by the National Cancer Institute (INT) of the Italian city of Milan shows, signaling that it might have spread beyond China earlier than thought. https://www.reuters.com/article/health-coronavirus-italy-timing-idUSKBN27W1J2 https://www.reuters.com/article/health-coronavirus-italy-tim... It is plausible that the virus was spread before recognized and treated as a global pandemic. Few flights were banned for months. Chinese tourists were in Italy up until the lockdowns. But very often this "appeared outside China" is deflection and falsely invoked. Mind you that Reuters write: "it might have spread beyond China earlier than thought". Not: It came from Italy to China, and only became problematic in Wuhan. Every time China is reluctantly forced to move back the timeline on its patient 0, it starts pushing a narrative of COVID outside of China just a few months before their patient 0. It is a tiring use of an obvious and plausible bait-and-switch. We already knew that Western expats and their relations in Wuhan got viral pneumonia in November 2019, while by January 2020, China did not consider it wise to inform the world of human-to-human transmission.
Fomite 6y ago
As someone who has colleagues who work in exactly this, it's not particularly surprising. Viral ecology is hard.

It tells you that that kind of analysis is extraordinarily difficult. How many documented three+ species viral evolution paths can you cite from the literature?

freeflight 6y ago

It took nearly a century to somewhat establish the geographical origin of the Spanish flu and even these results are still a bit controversial to this day [0]. The reality is that epidemiology is not a straight forward nor simple field of research, finding concrete and solid answers is usually way more difficult than most people assume when they want answers to point fingers. [0] https://academic.oup.com/emph/article/2019/1/18/5298310 https://academic.oup.com/emph/article/2019/1/18/5298310

gabaix 6y ago
Find and concrete answers is especially hard when the investigated actively hides and deflects.
bgandrew 6y ago
what I'm saying is that until the closest relative to SARS-CoV-2 is known to be exactly the same virus that was researched in Wuhan institute of virology, it's obvious that lab leak should be number 1 hypothesis. That wouldn't be so, if covid started in Beijing or Nanjing. Or if Wuhan wouldn't be home to one of the two BSL–4 labs in China. And the only lab to my mind that investigated SARS-CoV-2 closest known relative before the outbreak. But since all those facts are true, I really have a hard time considering other hypotheses.
- Uberphallus 6y ago
  SARS-CoV-2 was first detected in Wuhan, but it's not that clear that it's where it originated. The genetic divergence between RaTG13 and SARS-CoV-2 is explained with about 20 years of natural evolution, which puts the common ancestor somewhere in late 2000s, and given that bats migrate, the ancestor occurred potentially anywhere in Eurasia or even Africa. Post-hoc analysis of waste water and patient samples in Europe shows that it was circulating in Europe by mid-late 2019, way before the patient 0 in Wuhan. So the leak hypothesis, while feasible, would have to address why the virus was seemingly abroad before it became a problem in Wuhan itself. Of course it's a reasonable hypothesis, but putting it as number 1 is kind of reframing the whole picture.
  - bgandrew 6y ago
    "Post-hoc analysis of waste water and patient samples in Europe shows that it was circulating in Europe by mid-late 2019, way before the patient 0 in Wuhan." now this is what's called a conspiracy theory.
    - 2-tpg 6y ago
      > ROME (Reuters) - The new coronavirus was circulating in Italy in September 2019, a study by the National Cancer Institute (INT) of the Italian city of Milan shows, signaling that it might have spread beyond China earlier than thought. https://www.reuters.com/article/health-coronavirus-italy-timing-idUSKBN27W1J2 https://www.reuters.com/article/health-coronavirus-italy-tim... It is plausible that the virus was spread before recognized and treated as a global pandemic. Few flights were banned for months. Chinese tourists were in Italy up until the lockdowns. But very often this "appeared outside China" is deflection and falsely invoked. Mind you that Reuters write: "it might have spread beyond China earlier than thought". Not: It came from Italy to China, and only became problematic in Wuhan. Every time China is reluctantly forced to move back the timeline on its patient 0, it starts pushing a narrative of COVID outside of China just a few months before their patient 0. It is a tiring use of an obvious and plausible bait-and-switch. We already knew that Western expats and their relations in Wuhan got viral pneumonia in November 2019, while by January 2020, China did not consider it wise to inform the world of human-to-human transmission.

Fomite 6y ago

As someone who has colleagues who work in exactly this, it's not particularly surprising. Viral ecology is hard.