3 ms·
It's never been found in an influenza virus in nature, but covid isn't an influenza virus. Is this never found in coronaviruses in nature?
by bugzz 6y ago
It's never been found in an influenza virus in nature, but covid isn't an influenza virus. Is this never found in coronaviruses in nature?
- tshaddox 6y agoFrom that second link: > Although they only emerge under artificial conditions in influenza viruses, these furin cleavage sites are found within several branches of the coronavirus family tree. However SARS‐CoV‐2 is the only lineage B coronavirus found with one, and the only other coronaviruses known to have them are only at most 60% identical to this novel coronavirus.
- hn_throwaway_99 6y agoI'm not waynesonfire, but seriously, what is up with people making deliberately misleading claims (e.g. highlighting it is not found in influenza viruses, even though covid virus is not influenza), and then providing a link that specifically debunks the implication they are trying to make. It's like people just depend on nobody following the links they post.
- dang 6y ago"Please respond to the strongest plausible interpretation of what someone says, not a weaker one that's easier to criticize. Assume good faith." https://news.ycombinator.com/newsguidelines.html https://news.ycombinator.com/newsguidelines.html
- stonogo 6y agoHi dang, I am curious to know if this guideline applies only when responding to HN comments, or if it should be applied to source material in article links as well. I've noticed a lot more conspiracy-theorizing comments lately and it's hard to engage when the whole premise of a given comment is accusing someone else of misrepresenting facts. Thanks for all your hard work, regardless!
- koheripbal 6y agoI'm not Dang, but I think it's a generally good life lesson that should apply always.
- dang 6y agoIt totally applies to the articles too. That wasn't in my mind when we introduced that guideline but it turns out to apply just as nicely at that level.
- ekianjo 6y ago> However SARS‐CoV‐2 is the only lineage B coronavirus found with one It's unusual even for coronavirus.
- sudosysgen 6y agoDo you expect it to be unusual for coronaviruses that manage to cause a pandemic? Even if it is rare, as long as it is not unique, those priors are unbalanced.
- hn_throwaway_99 6y agoIt's really only unusual for lineage B coronaviruses: > Although they only emerge under artificial conditions in influenza viruses, these furin cleavage sites are found within several branches of the coronavirus family tree. Even the original quote, "In fact, no influenza virus with a furin cleavage site has ever been found in nature" leaves out something important: > the fact remains that every highly pathogenic avian influenza virus, defined by having a furin cleavage site, has either been found on commercial poultry farms that create the pseudo‐natural conditions necessary for serial passage, or created in laboratories with gain‐of‐function serial passage experiments. That is, the authors are defining "in nature" not to include commercial poultry farms.
- wahern 6y ago"Furin cleavage sites naturally occur in coronaviruses", https://www.sciencedirect.com/science/article/pii/S1873506120304165 https://www.sciencedirect.com/science/article/pii/S187350612...