There is a big difference between Guix and Nix and this area. Guix only accepts packages that can be fully bootstrapped, unlike Nix. It's a lot more effort, but

There is a big difference between Guix and Nix and this area. Guix only accepts packages that can be fully bootstrapped, unlike Nix. It's a lot more effort, but it means everything you install in the official Guix channel ultimately comes from a ~300 byte, auditable binary seed. Nix is more lenient when it comes to packages vendoring their own dependencies outside of Nix proper.