3 ms·

"proof of concept on the safe use of mRNA." Until about a year ago, potential treatments took 5-10 years of safety testing before general population use. This

"proof of concept on the safe use of mRNA." Until about a year ago, potential treatments took 5-10 years of safety testing before general population use. This stuff takes time for things like antibody-dependent enhancement to be found. What we do know is those who are obese have bad outcomes to C19. I am not obese, got it a couple months ago, and recovered with just home rest. Now I test positive for the antibodies.

hilbertseries 6y ago
Gonna need a citation on ADE taking time to discover. It’s typically caught in trials and we can run trials much faster during a pandemic.
- markus92 6y ago
  Typically caught in animal trials even, and surely something that would've been caught already with the amount of people already vaccinated.
ineedasername 6y ago
What we do know is those who are obese have bad outcomes That is such a blatant over simplification that it comes right up to the border of trolling, perhaps a bit over that border. It is incorrect on a level that practically defies any potential for a response due both to the impracticality of detailing here just how wrong it is, and the fact that a person who makes that sort of comment is unlikely to respond to anything argument that contradicts such a simplistic view of things. I'll at least address your reference to ADE by pointing out there might be a theoretical possibility there, things have worked out just fine in other illnesses even when know it can be an issue in-- for example-- measles, and yet a vaccine still knocked that out of general circulation a while ago until falsified research helped spark the anti-vaxxer movement and it gradually crept back in to un-vaccinated pockets of the population. Further, ERD simply does not take 5-10 years to detect. Congratulations on not being obese, and surviving Covid, but no one is debating the fact that most people don't die from it, so you've missed the mark significantly by using your own experience to justify your simplified view of the situation.
atleta 6y ago
Nope. It has been explained several times that 5-10 years wasn't needed because that's how long the actual testing took. It was partly due to funding issues, partly due to administrative issues, etc. E.g. the review process has been accelerated for COVID through two measures: - phase 1 & 2 could be done at once. Which increased risks for only those who participated in phase 2, obviously - phase 3 was evaluated with a rolling review. I.e. the manufacturers didn't wait until phase 3 was over and submit their data then, but did it so continuously. And also FDA & EMA started to process those right away. Then there is also the fact that when you don't have a pandemic (or even an epidemic) then it's hard to do a phase 3, because it will take a lot of time for enough people to get infected. Part of the reason the SARS1 vaccine was never finished (have never earned an authorization) is that it was over by the time the phase 3 would (or did) start. The same thing slowed down the ebola vaccine. The candidate was ready but then the outbreak vanished, so there was nowhere to do a phase 3.

hilbertseries 6y ago

Gonna need a citation on ADE taking time to discover. It’s typically caught in trials and we can run trials much faster during a pandemic.

markus92 6y ago
Typically caught in animal trials even, and surely something that would've been caught already with the amount of people already vaccinated.

ineedasername 6y ago

What we do know is those who are obese have bad outcomes That is such a blatant over simplification that it comes right up to the border of trolling, perhaps a bit over that border. It is incorrect on a level that practically defies any potential for a response due both to the impracticality of detailing here just how wrong it is, and the fact that a person who makes that sort of comment is unlikely to respond to anything argument that contradicts such a simplistic view of things. I'll at least address your reference to ADE by pointing out there might be a theoretical possibility there, things have worked out just fine in other illnesses even when know it can be an issue in-- for example-- measles, and yet a vaccine still knocked that out of general circulation a while ago until falsified research helped spark the anti-vaxxer movement and it gradually crept back in to un-vaccinated pockets of the population. Further, ERD simply does not take 5-10 years to detect. Congratulations on not being obese, and surviving Covid, but no one is debating the fact that most people don't die from it, so you've missed the mark significantly by using your own experience to justify your simplified view of the situation.

atleta 6y ago

Nope. It has been explained several times that 5-10 years wasn't needed because that's how long the actual testing took. It was partly due to funding issues, partly due to administrative issues, etc. E.g. the review process has been accelerated for COVID through two measures: - phase 1 & 2 could be done at once. Which increased risks for only those who participated in phase 2, obviously - phase 3 was evaluated with a rolling review. I.e. the manufacturers didn't wait until phase 3 was over and submit their data then, but did it so continuously. And also FDA & EMA started to process those right away. Then there is also the fact that when you don't have a pandemic (or even an epidemic) then it's hard to do a phase 3, because it will take a lot of time for enough people to get infected. Part of the reason the SARS1 vaccine was never finished (have never earned an authorization) is that it was over by the time the phase 3 would (or did) start. The same thing slowed down the ebola vaccine. The candidate was ready but then the outbreak vanished, so there was nowhere to do a phase 3.