3 ms·

Good they actually have some understanding of the underlying mechanism. Also this is an oral drug! It reduced mortality risk by 92%: https://www.europeanpharmac

Good they actually have some understanding of the underlying mechanism. Also this is an oral drug! It reduced mortality risk by 92%: https://www.europeanpharmaceuticalreview.com/news/147167/proxalutamide-reduces-covid-19-mortality-risk-by-92-percent/ https://www.europeanpharmaceuticalreview.com/news/147167/pro...

dang 6y ago
I've changed the URL above to that one from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899267/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899267/, which has the paper. Generally with specialized papers we've found that it's best to link to the best third-party article and then have a link to the paper in the thread. Unfortunately the third party article often isn't great, but it's at least an easier place to get some context, and we can replace the URL when people point out a better one.
- hu3 6y ago
  I appreciate it. Hopefully the trials can confirm this drug as another tool against covid.
DoofusOfDeath 6y ago
> Also this is an oral drug! Asking as a layman: Would that be a problem for patients who are unconscious or with breathing tubes?
- fspeech 6y ago
  You can always crush the pill and put it into the feeding tube.
sterlind 6y ago
Summarizing, it looks like the TMPRSS2 protein is necessary for the virus to replicate, and the Androgen Receptor modulates its transcription. But where I'm confused is why this drug in particular was studied, instead of an approved AR antagonist like bicalutamide or enzalutamide. Way easier to dispense those than some clinical trial drug, right? And is it important that the drug is a silent antagonist of AR rather than an inverse agonist? Also, how does this affect women? Are we at less risk of mortality through this mechanism? My T levels are very low, but all of us have androgens and their receptors. Maybe TMPRSS2 gets transcribed even when T or DHT levels are low?
- fspeech 6y ago
  All good questions. See the sibling comment that it may be too good to be true https://news.ycombinator.com/item?id=26517243 https://news.ycombinator.com/item?id=26517243

dang 6y ago

I've changed the URL above to that one from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899267/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899267/, which has the paper. Generally with specialized papers we've found that it's best to link to the best third-party article and then have a link to the paper in the thread. Unfortunately the third party article often isn't great, but it's at least an easier place to get some context, and we can replace the URL when people point out a better one.

hu3 6y ago
I appreciate it. Hopefully the trials can confirm this drug as another tool against covid.

DoofusOfDeath 6y ago

> Also this is an oral drug! Asking as a layman: Would that be a problem for patients who are unconscious or with breathing tubes?

fspeech 6y ago
You can always crush the pill and put it into the feeding tube.

sterlind 6y ago

Summarizing, it looks like the TMPRSS2 protein is necessary for the virus to replicate, and the Androgen Receptor modulates its transcription. But where I'm confused is why this drug in particular was studied, instead of an approved AR antagonist like bicalutamide or enzalutamide. Way easier to dispense those than some clinical trial drug, right? And is it important that the drug is a silent antagonist of AR rather than an inverse agonist? Also, how does this affect women? Are we at less risk of mortality through this mechanism? My T levels are very low, but all of us have androgens and their receptors. Maybe TMPRSS2 gets transcribed even when T or DHT levels are low?

fspeech 6y ago
All good questions. See the sibling comment that it may be too good to be true https://news.ycombinator.com/item?id=26517243 https://news.ycombinator.com/item?id=26517243