IANA physicist or neuroscientist but I think one open question is whether mechanistic causality is sufficient to describe/model living beings, or even non-life.

IANA physicist or neuroscientist but I think one open question is whether mechanistic causality is sufficient to describe/model living beings, or even non-life. See Wheeler and Feynman's interpretation of electrodynamics for instance, which rejects time-reversal symmetry breaking and proposes that both solutions of Maxwell's equations are metaphysically meaningful. I am not aware of any consensus on how causality actually works. Any physicists reading this, yell at me if I'm wrong.