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AZ vaccine is made with a genetically engineered Chimpanzee virus, ChAdOx1 . It makes me uneasy. Zoonotic viruses tend to be more dangerous the closer related t

AZ vaccine is made with a genetically engineered Chimpanzee virus, ChAdOx1 . It makes me uneasy. Zoonotic viruses tend to be more dangerous the closer related the species. There's plenty of human viruses that seem harmless like flu except for rare cases where they kill. How do we know that ChAdOx1 is not one of these? I would be less worried if they used a fish virus or something. My primary concern is using a virus from such a closely related species. The mRNA approach without a live virus seems safer

petertodd 6y ago
The AZ vaccine needs to be able to enter your cells to work. That limits it to viruses that started off being able to infect you; we're not vulnerable to very many fish viruses. There's also the problem that we eat fish, and thus get exposed to fish viruses: one of the problems with using carrier viruses is you can already have immunity to them. If you do, the vaccine can be destroyed prior to it entering your cells, prior to it being able to induce those cells to create the spike protein that leads to COVID-19 immunity. https://www.medicalnewstoday.com/articles/covid-19-how-do-viral-vector-vaccines-work https://www.medicalnewstoday.com/articles/covid-19-how-do-vi...