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This article talks about at least one tweak that Pfizer, Moderna and J&J do that AZ doesnt https://cen.acs.org/pharmaceuticals/vaccines/tiny-tweak-behind-COVID

• Throwawayaerlei 6y ago
  I've heard this multiple times, but never with a citation. Can you point us at anything? Trying to prove a negative with searches hasn't worked for me so far, and this vaccine is not a good option for me so I haven't trying looking up and parsing its spike protein nucleotide or amino acid sequence. However all these vaccines you listed coerce a small number of your cells to make spike proteins of whatever sort, which results in bits of them being put on the surface of the cells. I don't know how much of the spike protein gets outside cells, either through direct escape or creation of new viruses, have not looked up the exact details of what J&J and Oxford mean by their viral vectors being replication deficient. That is, they don't produce new viruses that can attack other cells.