3 ms·
It's not the percentage of intact mRNA that's the problem, it's what the other bits of mRNA happen to do.
by ppf 6y ago
It's not the percentage of intact mRNA that's the problem, it's what the other bits of mRNA happen to do.
- et2o 6y agoEncode smaller bits of the same protein? Who cares. Otherwise, the mRNAs aren’t present in high enough quantities to do significant signaling or silencing things, and it’s going in the deltoid... not really a medically interesting place. You could inject 1mL of dilute HCl there and it wouldn’t be a big problem.
- ppf 6y agoI'd rather not be injected with bits of mRNA that encode random bits of proteins, thanks. The deltoid is "medically interesting" enough to produce Covid spike proteins.
- timy2shoes 6y agoWon't non-intact mRNA without a stop codon get degraded by Non-stop decay?
- rolph 6y agoyou have the idea right , but it isnt a stop codon its a signal sequence on the mRNA that would give it a hall pass. no cytoplasmic nucleotide transport signal and it gets degraded quickly.
- et2o 6y agoDon’t get the vaccine then, because you are getting small pieces of mRNA.
- Tossitto 6y agoProteopathy is a real thing. Prion dysfunctions can cause self-replication, not that the makeup is necessarily there for that in these vaccines. Interesting starting point for consideration nonetheless.
- cfu28 6y agoAnything particular reason you're worried about extra mRNA fragments? mRNA needs a initiation sequence in order to be translated into a protein, which only exists at the front. It also needs a polyA tail to maintain stability or it would just degrade. Random fragments don't do anything on their own
- rolph 6y agothese fragments of mRNA will be recognized as antigens, until the point that the folded structure of the epitopes is destroyed, these smaller fragments are still recognized as viral PAMPs and evoke innate immune responses.
- topynate 6y agoDidn't I cover that in "danger"? The leaks are talking about maybe twice as much broken bits of mRNA in early batches. That's assuming all the not-intact stuff is broken mRNA rather than simple amino acids or something else just as boring. That shouldn't make much difference to anyone's view. If you think it's "doing" stuff that makes you not want to get vaccinated, well you probably thought that before you read this report, too.