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There isn't one. Mitochondria won't decode the corrupted mRNA and it will be broken down into constituent parts that are reused by the body. Edit: Oops, ribos

There isn't one. Mitochondria won't decode the corrupted mRNA and it will be broken down into constituent parts that are reused by the body. Edit: Oops, ribosomes, not mitochondria.

DSingularity 6y ago
How do we guarantee that? Is there a biological equivalent of a checksum?
- maxerickson 6y ago
  You have trillions of mitochondria. Do you think there is no error correction present? (The actual estimate is 10 million billion...) Edit following my other edit: each cell has something like 10 million ribosomes.
- serf 6y ago
  NMD does similar work, but not in a checksum-like way. https://en.wikipedia.org/wiki/Nonsense-mediated_decay https://en.wikipedia.org/wiki/Nonsense-mediated_decay
walterbell 6y ago
Any pointers to reading material on the detection process? A web search found this article. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791314/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791314/ > Given the central role of RNA in many fundamental biological processes, including translation and splicing, changes to its chemical composition can have a detrimental impact on cellular fitness, with some evidence suggesting that RNA damage has roles in diseases such as neurodegenerative disorders. We are only just beginning to learn about how cells cope with RNA damage, with recent studies revealing the existence of quality-control processes that are capable of recognizing and degrading or repairing damaged RNA.
- Zancarius 6y ago
  That article discusses RNA not mRNA (messenger RNA). mRNA is used by ribosomes to "print" proteins. Totally different thing.
phkahler 6y ago
How does it recognize corruption? Certainly some could be processed with incomplete or incorrect results. It's really hard (probably impossible) to show that there will not be negative effects from that.
- taipan100 6y ago
  Valid mRNA has a start codon and a stop codon. Without these mRNA will be broken down and untranslated. However without translation the vaccine will be useless. So while unintended translation is unlikely it is possible that efficacy would be impacted.

There isn't one. Mitochondria won't decode the corrupted mRNA and it will be broken down into constituent parts that are reused by the body. Edit: Oops, ribosomes, not mitochondria.

DSingularity 6y ago

How do we guarantee that? Is there a biological equivalent of a checksum?

maxerickson 6y ago
You have trillions of mitochondria. Do you think there is no error correction present? (The actual estimate is 10 million billion...) Edit following my other edit: each cell has something like 10 million ribosomes.
serf 6y ago
NMD does similar work, but not in a checksum-like way. https://en.wikipedia.org/wiki/Nonsense-mediated_decay https://en.wikipedia.org/wiki/Nonsense-mediated_decay

walterbell 6y ago

Any pointers to reading material on the detection process? A web search found this article. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791314/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791314/ > Given the central role of RNA in many fundamental biological processes, including translation and splicing, changes to its chemical composition can have a detrimental impact on cellular fitness, with some evidence suggesting that RNA damage has roles in diseases such as neurodegenerative disorders. We are only just beginning to learn about how cells cope with RNA damage, with recent studies revealing the existence of quality-control processes that are capable of recognizing and degrading or repairing damaged RNA.

Zancarius 6y ago
That article discusses RNA not mRNA (messenger RNA). mRNA is used by ribosomes to "print" proteins. Totally different thing.

phkahler 6y ago

How does it recognize corruption? Certainly some could be processed with incomplete or incorrect results. It's really hard (probably impossible) to show that there will not be negative effects from that.

taipan100 6y ago
Valid mRNA has a start codon and a stop codon. Without these mRNA will be broken down and untranslated. However without translation the vaccine will be useless. So while unintended translation is unlikely it is possible that efficacy would be impacted.