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Wait, so what effect does potential RNA instability really have?
by possiblelion 6y ago
Wait, so what effect does potential RNA instability really have?
- maxerickson 6y agoThe mRNA is the instruction that the body follows to produce the viral proteins that lead to an immune response. If the mRNA in a batch of vaccine degrades more than they have allowed for in the treatment protocol, it may not work. (This is one of the reasons they have very specific handling rules and throw out vaccine that is improperly handled)
- walterbell 6y agohttps://www.modernatx.com/about-us https://www.modernatx.com/about-us > Welcome to Moderna. We believe mRNA is the “software of life." Every cell in the body uses mRNA to provide real-time instructions to make the proteins necessary to drive all aspects of biology, including in human health and disease. What's the metaphorical software equivalent of "mRNA instability": undefined reference, memory corruption, incomplete download, installation failure, program crash, ...?
- nobrains 6y agohttps://remyhax.xyz/posts/bitsquatting-windows/ https://remyhax.xyz/posts/bitsquatting-windows/
- maxerickson 6y agoThere isn't one. Mitochondria won't decode the corrupted mRNA and it will be broken down into constituent parts that are reused by the body. Edit: Oops, ribosomes, not mitochondria.
- DSingularity 6y agoHow do we guarantee that? Is there a biological equivalent of a checksum?
- maxerickson 6y agoYou have trillions of mitochondria. Do you think there is no error correction present? (The actual estimate is 10 million billion...) Edit following my other edit: each cell has something like 10 million ribosomes.
- serf 6y agoNMD does similar work, but not in a checksum-like way. https://en.wikipedia.org/wiki/Nonsense-mediated_decay https://en.wikipedia.org/wiki/Nonsense-mediated_decay
- walterbell 6y agoAny pointers to reading material on the detection process? A web search found this article. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791314/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791314/ > Given the central role of RNA in many fundamental biological processes, including translation and splicing, changes to its chemical composition can have a detrimental impact on cellular fitness, with some evidence suggesting that RNA damage has roles in diseases such as neurodegenerative disorders. We are only just beginning to learn about how cells cope with RNA damage, with recent studies revealing the existence of quality-control processes that are capable of recognizing and degrading or repairing damaged RNA.
- Zancarius 6y agoThat article discusses RNA not mRNA (messenger RNA). mRNA is used by ribosomes to "print" proteins. Totally different thing.
- phkahler 6y agoHow does it recognize corruption? Certainly some could be processed with incomplete or incorrect results. It's really hard (probably impossible) to show that there will not be negative effects from that.
- taipan100 6y agoValid mRNA has a start codon and a stop codon. Without these mRNA will be broken down and untranslated. However without translation the vaccine will be useless. So while unintended translation is unlikely it is possible that efficacy would be impacted.
- ceejayoz 6y ago> What's the metaphorical software equivalent of "mRNA instability" “This shitty app doesn’t work. Uninstall.” That’s about it here.
- astrange 6y agoCorrupted TCP packets, except it's much harder to get the origin to resend.