I would also avoid them because: https://pubmed.ncbi.nlm.nih.gov/7678175/ https://pubmed.ncbi.nlm.nih.gov/7678175/ > Compared to a potent eukaryotic DNA topois

I would also avoid them because: https://pubmed.ncbi.nlm.nih.gov/7678175/ https://pubmed.ncbi.nlm.nih.gov/7678175/ > Compared to a potent eukaryotic DNA topoisomerase type II poison ... ciprofloxacin produced comparable dose-dependent SCE frequency increases. Translated: Compared to a chemotherapy drug designed to cause DNA breaks to prevent cell replication, ciprofloxacin produced similar "sister chromatid exchange" counts, which happen when damaged DNA strands need to pull in duplicate material from "sister" strands. Counting SCEs is also used to measure human DNA mutations from things like carcinogens and radiation.