5 ms·

Can it be reversed? Can we increase myelination? Is this what senolytics do?

deleted 6y ago
[deleted]
dogma1138 6y ago
https://www.mayoclinic.org/medical-professionals/physical-medicine-rehabilitation/news/analyzing-the-role-of-diet-and-exercise-in-myelin-production/mac-20429394 https://www.mayoclinic.org/medical-professionals/physical-me...
- posix_compliant 6y ago
  Very interesting. The standard caveat regarding mouse-human equivalence, but once again it seems that exercise is good for neurological fitness.
mjfl 6y ago
Senolytics cause the lysis of senescent cells- something else. So unlikely they would directly contribute here.
jjcc 6y ago
I don't know about reverse. But as I remeber according to Dr.Rhonda Patric in one of Joe Rogan show, cold shower can boost protection of myelin. Senolytics might help reducing aged cells to get benefit. Not directly contribute to brain health I think.
- collyw 6y ago
  I like Rhonda Patrick, but a lot of her recommendations seem to be speculation on what should work, given what she understands about a subject and relating it to a new study. Not that it's not valuable, but it's the sort of thing Reddit would class as "science" rather than realising it is a hypothesis that needs testing.
SailingSperm 6y ago
Hericium erinaceus (Lion's mane mushroom) has isolates called Hericenones and Erinacine that promote nerve growth factor synthesis and a lot of other Neurohealth benifits being found to do with the compounds the fungi produces. The influence of Hericium erinaceus extract on myelination process in vitro https://pubmed.ncbi.nlm.nih.gov/12675022/ https://pubmed.ncbi.nlm.nih.gov/12675022/ Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987239/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987239/ Protip: If/When buying supplements -- There's many that are just selling capsules of ground myceliated brf (brown rice flour - the substrate inoculated/grown on). Mycelium is the 'roots/pre fruiting stage' of the fungi -- The fruit body/ mushroom itself has much greater concentrations of the desired compounds.
- NalNezumi 6y ago
  Was about to write this. Here's also an easy summary of it's effect and recommendation If one consider buying supplements: https://www.reddit.com/r/MushroomSupplements/comments/h090ry/lions_mane_best_supplements_how_it_works/ https://www.reddit.com/r/MushroomSupplements/comments/h090ry... Bought some myself and tried to track its effect by playing 3DS Devilish Brain Training game and track performance.
  - sail0rm00n 6y ago
    Did you notice an improvement?
    - NalNezumi 6y ago
      Nothing definitive. After 1 week I managed to achieve life-time high score in focus and short-term memory task (my previous high-score was from Uni while studying Physics), but I'm susceptible to placebo so I can't rule out that effect. I feel like I have less "brain-fog" or rather, brain-fog induced procrastination though. But taking this coincided with a less-stressful time of my life so It might be related to both.
- jonathanleane 6y ago
nom 6y ago
I'd be surprised if we manage to reverse deterioration in such a complex system as the human body, especially in the brain, in our lifetime. We are barely scratching the surface, trying to understand the most basic interactions between this massive amount of variables of which we can only control a few reliably.
- The_rationalist 6y ago
  The problem is conceptually quite simple: Ageing is an accumulation of degradations in our DNAs. We just need to reset/monkey patch our DNAs with a prior younger version through CRIPSR + viral vectors. The only issue is the scale of the gene therapy (changing whole organs) but I'm quite sure it is doable, just underresearched/underfunded. 1 March – Scientists use lipid nanoparticles to deliver CRISPR genome editing into the livers of mice, resulting in a 57% reduction of cholesterol levels.[160] Rejuvenation is not science fiction, it just require funding but expecting this from humanity might be considered science fiction and the situation isn't going to improve given than the Flynn effect is reversing.. See also those related thoughts I wrote years ago: https://github.com/LifeIsStrange/An-algorithm-for-curing-ageing https://github.com/LifeIsStrange/An-algorithm-for-curing-age...
booleanbetrayal 6y ago
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219542/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219542/ TL;DR - CBD may offer a pathway to help control the inflammatory threat to the myelin sheath.
rsync 6y ago
"Is this what senolytics do?" I learned today that senolytics are molecules that "... can selectively induce death of senescent cells ..."[1] Which is interesting but you can already do this with exercise. Nick Lane wrote a fascinating book[2] about this subject which suggests that your internal mitochondrial population is under selection pressure from your own activity. If you don't put any pressure on it, energetically ill-performing cells are allowed to thrive. [1] https://en.wikipedia.org/wiki/Senolytic https://en.wikipedia.org/wiki/Senolytic [2] _Power, Sex, Suicide_
citboin 6y ago
I have M.S.. My question is can remyelination from Lion’s Mane outpace the demyelination from M.S.
- hinkley 6y ago
  Tai chi, if you still can. Helps substantially with balance, which should give you some more time on your own feet.
wtetzner 6y ago
Here’s a talk by Dr. Terry Wahls, who reversed her MS through diet: https://www.youtube.com/watch?v=KLjgBLwH3Wc https://www.youtube.com/watch?v=KLjgBLwH3Wc
vector_spaces 6y ago
Vitamin B12 is pretty critical for remyelonation and preventing demyelination. I'm not sure whether it's been studied in age related demyelination
jzer0cool 6y ago
I like to understand this too, substance called ‘myelin. Is there some intake of food that can help? Just like my parents to be including anything in their diet that can help.

deleted 6y ago

[deleted]

https://www.mayoclinic.org/medical-professionals/physical-medicine-rehabilitation/news/analyzing-the-role-of-diet-and-exercise-in-myelin-production/mac-20429394 https://www.mayoclinic.org/medical-professionals/physical-me...

posix_compliant 6y ago
Very interesting. The standard caveat regarding mouse-human equivalence, but once again it seems that exercise is good for neurological fitness.

mjfl 6y ago

Senolytics cause the lysis of senescent cells- something else. So unlikely they would directly contribute here.

jjcc 6y ago

I don't know about reverse. But as I remeber according to Dr.Rhonda Patric in one of Joe Rogan show, cold shower can boost protection of myelin. Senolytics might help reducing aged cells to get benefit. Not directly contribute to brain health I think.

collyw 6y ago
I like Rhonda Patrick, but a lot of her recommendations seem to be speculation on what should work, given what she understands about a subject and relating it to a new study. Not that it's not valuable, but it's the sort of thing Reddit would class as "science" rather than realising it is a hypothesis that needs testing.

SailingSperm 6y ago

Hericium erinaceus (Lion's mane mushroom) has isolates called Hericenones and Erinacine that promote nerve growth factor synthesis and a lot of other Neurohealth benifits being found to do with the compounds the fungi produces. The influence of Hericium erinaceus extract on myelination process in vitro https://pubmed.ncbi.nlm.nih.gov/12675022/ https://pubmed.ncbi.nlm.nih.gov/12675022/ Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987239/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987239/ Protip: If/When buying supplements -- There's many that are just selling capsules of ground myceliated brf (brown rice flour - the substrate inoculated/grown on). Mycelium is the 'roots/pre fruiting stage' of the fungi -- The fruit body/ mushroom itself has much greater concentrations of the desired compounds.

NalNezumi 6y ago
Was about to write this. Here's also an easy summary of it's effect and recommendation If one consider buying supplements: https://www.reddit.com/r/MushroomSupplements/comments/h090ry/lions_mane_best_supplements_how_it_works/ https://www.reddit.com/r/MushroomSupplements/comments/h090ry... Bought some myself and tried to track its effect by playing 3DS Devilish Brain Training game and track performance.
- sail0rm00n 6y ago
  Did you notice an improvement?
  - NalNezumi 6y ago
    Nothing definitive. After 1 week I managed to achieve life-time high score in focus and short-term memory task (my previous high-score was from Uni while studying Physics), but I'm susceptible to placebo so I can't rule out that effect. I feel like I have less "brain-fog" or rather, brain-fog induced procrastination though. But taking this coincided with a less-stressful time of my life so It might be related to both.
jonathanleane 6y ago

nom 6y ago

I'd be surprised if we manage to reverse deterioration in such a complex system as the human body, especially in the brain, in our lifetime. We are barely scratching the surface, trying to understand the most basic interactions between this massive amount of variables of which we can only control a few reliably.

The_rationalist 6y ago
The problem is conceptually quite simple: Ageing is an accumulation of degradations in our DNAs. We just need to reset/monkey patch our DNAs with a prior younger version through CRIPSR + viral vectors. The only issue is the scale of the gene therapy (changing whole organs) but I'm quite sure it is doable, just underresearched/underfunded. 1 March – Scientists use lipid nanoparticles to deliver CRISPR genome editing into the livers of mice, resulting in a 57% reduction of cholesterol levels.[160] Rejuvenation is not science fiction, it just require funding but expecting this from humanity might be considered science fiction and the situation isn't going to improve given than the Flynn effect is reversing.. See also those related thoughts I wrote years ago: https://github.com/LifeIsStrange/An-algorithm-for-curing-ageing https://github.com/LifeIsStrange/An-algorithm-for-curing-age...

booleanbetrayal 6y ago

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219542/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219542/ TL;DR - CBD may offer a pathway to help control the inflammatory threat to the myelin sheath.

rsync 6y ago

"Is this what senolytics do?" I learned today that senolytics are molecules that "... can selectively induce death of senescent cells ..."[1] Which is interesting but you can already do this with exercise. Nick Lane wrote a fascinating book[2] about this subject which suggests that your internal mitochondrial population is under selection pressure from your own activity. If you don't put any pressure on it, energetically ill-performing cells are allowed to thrive. [1] https://en.wikipedia.org/wiki/Senolytic https://en.wikipedia.org/wiki/Senolytic [2] _Power, Sex, Suicide_

citboin 6y ago

I have M.S.. My question is can remyelination from Lion’s Mane outpace the demyelination from M.S.

hinkley 6y ago
Tai chi, if you still can. Helps substantially with balance, which should give you some more time on your own feet.

wtetzner 6y ago

Here’s a talk by Dr. Terry Wahls, who reversed her MS through diet: https://www.youtube.com/watch?v=KLjgBLwH3Wc https://www.youtube.com/watch?v=KLjgBLwH3Wc

vector_spaces 6y ago

Vitamin B12 is pretty critical for remyelonation and preventing demyelination. I'm not sure whether it's been studied in age related demyelination

jzer0cool 6y ago

I like to understand this too, substance called ‘myelin. Is there some intake of food that can help? Just like my parents to be including anything in their diet that can help.