4 ms·

I have done my PhD on T cell activation. The persistent focus of the media and even some of the science community on Antibody induced immunity was completely be

by baxtr 6y ago

I have done my PhD on T cell activation. The persistent focus of the media and even some of the science community on Antibody induced immunity was completely beyond me. T cells were largely simply ignored even though they play such a crucial role in the body’s immune response. Antibodies seem to be a concept much easier to grasp. Maybe we should call T cells "Police Cells or "Anti-Cells" instead. You know, some marketing might help...

walterbell 6y ago
Good idea! Infographic, logo, spokesperson.
- girvo 6y ago
  And a cute branded website, treat it like one of those named exploits perhaps?
  - walterbell 6y ago
    Yep, it is competing for research resources and media attention. This opinion piece used the phrase "T Cells: Warriors of SARS-CoV-2 Infection", https://www.cell.com/trends/immunology/fulltext/S1471-4906(20)30260-X https://www.cell.com/trends/immunology/fulltext/S1471-4906(2... UK Science Museum 2-pager with diagrams (https://www.immunology.org/public-information/bitesized-immunology/systems-and-processes/t-cell-activation https://www.immunology.org/public-information/bitesized-immu...) and UCB lecture slides (http://mcb.berkeley.edu/courses/mcb150/Lecture15/Lecture15(6).pdf http://mcb.berkeley.edu/courses/mcb150/Lecture15/Lecture15(6...) Maybe vendors (e.g. https://www.rndsystems.com/research-area/t-cell-kits https://www.rndsystems.com/research-area/t-cell-kits) would support a T-cell microsite, with dedicated sections for science journalists, academics and industry scientists. A vendor created this poster on T-cell subsets: https://docs.abcam.com/pdf/immunology/t_cells_the_usual_subsets.pdf https://docs.abcam.com/pdf/immunology/t_cells_the_usual_subs... This 2018 effort looks useful, https://github.com/hammerlab/t-cell-guide https://github.com/hammerlab/t-cell-guide > We provide practical hints and tips on basic cellular and molecular techniques for handling primary human T cells. We hope that this guide will serve as a reference point to evaluate, discuss, and improve current practices in T cell culturing and manipulation. Oh wow, there are T cell cartoons :) https://cellcartoons.net/character/cd8tcell https://cellcartoons.net/character/cd8tcell & https://cellcartoons.net/character/cd4tcell https://cellcartoons.net/character/cd4tcell And a manga/anime called Cells at Work! (https://mangarock.to/manga/1684/cells-at-work/first-chapter#lg=1&slide=0 https://mangarock.to/manga/1684/cells-at-work/first-chapter#...) whose final (June 2021) installment covers Covid-19. There's also a character called Killer T Cell, https://cellsatwork.fandom.com/wiki/Killer_T_Cell_(Squad_Leader) https://cellsatwork.fandom.com/wiki/Killer_T_Cell_(Squad_Lea... > Killer T Cell is loud, obnoxious, and quick-tempered, resulting in rivalries with many cells. He also despises it when a non-white blood cell forms a friendship or relationship with one of his kind. As an immature thymocyte he went through training at Thymus school, where apprentice cells like himself learn to become Mature Thymocytes. Season 1 is streaming: https://www.netflix.com/title/81028791 https://www.netflix.com/title/81028791 Possible seeds for a github-pages microsite..
- garaetjjte 6y ago
  They were also featured in Once Upon a Time... Life... https://static.wikia.nocookie.net/once-upon-a-time-life/images/a/aa/Lymphocytes_t.png https://static.wikia.nocookie.net/once-upon-a-time-life/imag... (from https://once-upon-a-time-life.fandom.com/wiki/Lymphocytes https://once-upon-a-time-life.fandom.com/wiki/Lymphocytes)
  - walterbell 6y ago
    Thanks!
type0 6y ago
T cell activation is readily misunderstood even among some cell biologists. There's a lot of people in life science academia who desperately need to update their knowledge about the recent discoveries in Immunology.
8ytecoder 6y ago
Are vaccines necessary for someone who has had covid? If it was absolutely necessary to prioritise those who don’t have any immunity at all, is there a test that can help identify with that?
- walterbell 6y ago
  The FDA recently approved the first test of T-cells to determine whether someone was previously infected by Covid, https://abcnews.go.com/Health/fda-authorizes-cell-test-game-changer-covid-19/story?id=76318248 https://abcnews.go.com/Health/fda-authorizes-cell-test-game-... >The test is administered via blood draw. T-cell DNA is then extracted and sequenced with Microsoft's artificial intelligence, mapping out the immune system's "massive black box" data into navigable science, researchers say.
simonebrunozzi 6y ago
> Maybe we should call T cells "Police Cells or "Anti-Cells" instead. You know, some marketing might help... Sad, but probably very true...
divbzero 6y ago
I like the sound of “anticell” which also suggests a function complementary to “antibody”.
- tonfreed 6y ago
  It's sounds like a capeshit villain

by baxtr 6y ago

walterbell 6y ago

Good idea! Infographic, logo, spokesperson.

girvo 6y ago
And a cute branded website, treat it like one of those named exploits perhaps?
- walterbell 6y ago
  Yep, it is competing for research resources and media attention. This opinion piece used the phrase "T Cells: Warriors of SARS-CoV-2 Infection", https://www.cell.com/trends/immunology/fulltext/S1471-4906(20)30260-X https://www.cell.com/trends/immunology/fulltext/S1471-4906(2... UK Science Museum 2-pager with diagrams (https://www.immunology.org/public-information/bitesized-immunology/systems-and-processes/t-cell-activation https://www.immunology.org/public-information/bitesized-immu...) and UCB lecture slides (http://mcb.berkeley.edu/courses/mcb150/Lecture15/Lecture15(6).pdf http://mcb.berkeley.edu/courses/mcb150/Lecture15/Lecture15(6...) Maybe vendors (e.g. https://www.rndsystems.com/research-area/t-cell-kits https://www.rndsystems.com/research-area/t-cell-kits) would support a T-cell microsite, with dedicated sections for science journalists, academics and industry scientists. A vendor created this poster on T-cell subsets: https://docs.abcam.com/pdf/immunology/t_cells_the_usual_subsets.pdf https://docs.abcam.com/pdf/immunology/t_cells_the_usual_subs... This 2018 effort looks useful, https://github.com/hammerlab/t-cell-guide https://github.com/hammerlab/t-cell-guide > We provide practical hints and tips on basic cellular and molecular techniques for handling primary human T cells. We hope that this guide will serve as a reference point to evaluate, discuss, and improve current practices in T cell culturing and manipulation. Oh wow, there are T cell cartoons :) https://cellcartoons.net/character/cd8tcell https://cellcartoons.net/character/cd8tcell & https://cellcartoons.net/character/cd4tcell https://cellcartoons.net/character/cd4tcell And a manga/anime called Cells at Work! (https://mangarock.to/manga/1684/cells-at-work/first-chapter#lg=1&slide=0 https://mangarock.to/manga/1684/cells-at-work/first-chapter#...) whose final (June 2021) installment covers Covid-19. There's also a character called Killer T Cell, https://cellsatwork.fandom.com/wiki/Killer_T_Cell_(Squad_Leader) https://cellsatwork.fandom.com/wiki/Killer_T_Cell_(Squad_Lea... > Killer T Cell is loud, obnoxious, and quick-tempered, resulting in rivalries with many cells. He also despises it when a non-white blood cell forms a friendship or relationship with one of his kind. As an immature thymocyte he went through training at Thymus school, where apprentice cells like himself learn to become Mature Thymocytes. Season 1 is streaming: https://www.netflix.com/title/81028791 https://www.netflix.com/title/81028791 Possible seeds for a github-pages microsite..
garaetjjte 6y ago
They were also featured in Once Upon a Time... Life... https://static.wikia.nocookie.net/once-upon-a-time-life/images/a/aa/Lymphocytes_t.png https://static.wikia.nocookie.net/once-upon-a-time-life/imag... (from https://once-upon-a-time-life.fandom.com/wiki/Lymphocytes https://once-upon-a-time-life.fandom.com/wiki/Lymphocytes)
- walterbell 6y ago
  Thanks!

type0 6y ago

T cell activation is readily misunderstood even among some cell biologists. There's a lot of people in life science academia who desperately need to update their knowledge about the recent discoveries in Immunology.

8ytecoder 6y ago

Are vaccines necessary for someone who has had covid? If it was absolutely necessary to prioritise those who don’t have any immunity at all, is there a test that can help identify with that?

walterbell 6y ago
The FDA recently approved the first test of T-cells to determine whether someone was previously infected by Covid, https://abcnews.go.com/Health/fda-authorizes-cell-test-game-changer-covid-19/story?id=76318248 https://abcnews.go.com/Health/fda-authorizes-cell-test-game-... >The test is administered via blood draw. T-cell DNA is then extracted and sequenced with Microsoft's artificial intelligence, mapping out the immune system's "massive black box" data into navigable science, researchers say.

simonebrunozzi 6y ago

> Maybe we should call T cells "Police Cells or "Anti-Cells" instead. You know, some marketing might help... Sad, but probably very true...

divbzero 6y ago

I like the sound of “anticell” which also suggests a function complementary to “antibody”.

tonfreed 6y ago
It's sounds like a capeshit villain