No. It inherently cannot. Pi-Hole isn't a proxy where all traffic is flowing through it and has a chance to be modified. Pi-Hole is strictly answering the quest

No. It inherently cannot. Pi-Hole isn't a proxy where all traffic is flowing through it and has a chance to be modified. Pi-Hole is strictly answering the question, "What is the IP address for this hostname?" If a given hostname is known to host trackers or something undesirable Pi-Hole will claim it's an unknown host so the device is unable to reach it.