One problem is mice aren't humans. In many cases research done on mice ends up being overly pessimistic, because the short lifespans of mice compared to humans

One problem is mice aren't humans. In many cases research done on mice ends up being overly pessimistic, because the short lifespans of mice compared to humans means there is less evolutionary pressure to be resilient to cancers and other diseases of aging. Equally, in other circumstances they'll be more resilient, because they don't live long enough to see the effects of longer term toxins. And of course, there can be differences in specific metabolic pathways. So yes, it certainly would be good to do more of that research. But there's limits to what it can tell us.