Well I've used modern frameworks and it's still far from running exactly the same across all browsers and OS's - especially if you'd like to use CSS3/HTML5. It

Well I've used modern frameworks and it's still far from running exactly the same across all browsers and OS's - especially if you'd like to use CSS3/HTML5. It's still a major pain in the ass to do something as simple as center a div vertically on a page. I don't consider that modern.