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This doesn't really seem to address how they work, in two fundamental ways: 1) We've had a good idea of the pharmacokinetics for a little while. All this resea
by ineedasername 6y ago
This doesn't really seem to address how they work, in two fundamental ways:
1) We've had a good idea of the pharmacokinetics for a little while. All this research does is enhance that knowledge and take it one level deeper. Essentially, we've just gone one turtle lower in the pile of turtles standing on backs.
2) No theory of how antidepressants work will complete until we also understand why they so often do not work for many people.
- maybelsyrup 6y agoAgreed. This article doesn't address "how they work" - whether they "work" in the first place isn't at all clear, given how often they appear to either harm their users or simply do nothing - it's just elucidating "what they do" a little further. Two very different questions. No small task, of course, and the paper's pretty interesting, but it's not clear this has anything to do with what we call depression.
- dwaltrip 6y agoPrior to this article, I’ve never heard of the theory that SSRIs works by improving BDNF. Was this actually a widely accepted possibility?