4 ms·
Where do you see SNRI lowers serotonin? It's a re-uptake inhibitor for both serotonin and norepinephrine which keeps your body from flushing our those chemical
by m00x 6y ago
Where do you see SNRI lowers serotonin?
It's a re-uptake inhibitor for both serotonin and norepinephrine which keeps your body from flushing our those chemicals which raises serotonin levels as long as production is stable.
High doses of SNRI will contribute to Serotonin syndrome, which makes your argument hard to believe.
- astrange 6y agoOh, I was going from memory, so I guess that part's wrong. But there are effective antidepressants that aren't strongly based on the serotonin effects SSRIs have, like trazodone (weakly increases it) and especially ketamine (doesn't do it, works better than most antidepressants, works near-instantly instead of taking weeks).
- johnisgood 6y agoAnd I would like to add that ketamine has nothing to do with the monoamine hypothesis, it is an NMDA receptor antagonist. It has nothing to do with serotonin, dopamine, and noradrenalin. See my other comment about the growing interest in the glutamate system instead of serotonin and the like.
- texasbigdata 6y agoCan you please explain what seratonin syndrome is, particularly (like the above hypnosis / nlp split) where the edge of medical literature is? Highly interested, however for some reason was previously inclided to believe the phenomenon did not exist, akin to how adrenal fatigue can't be proven.