One source I've found about the long-term effects: https://www.drugabuse.gov/publications/research-reports/heroin/what-are-long-term-effects-heroin-use https://

One source I've found about the long-term effects: https://www.drugabuse.gov/publications/research-reports/heroin/what-are-long-term-effects-heroin-use https://www.drugabuse.gov/publications/research-reports/hero... "Repeated heroin use changes the physical structure and physiology of the brain, creating long-term imbalances in neuronal and hormonal systems that are not easily reversed. Studies have shown some deterioration of the brain’s white matter due to heroin use, which may affect decision-making abilities, the ability to regulate behavior, and responses to stressful situations." I expected something more damning. Unfortunately, I feel that we don't have enough studies (incl. long-term ones) when it comes to recreational drugs.