Every company I've joined has been in a new field that I have never had experience with previously, and that doesn't seem all that rare. People are fairly adapt

Every company I've joined has been in a new field that I have never had experience with previously, and that doesn't seem all that rare. People are fairly adaptive. That VP of sales and CTO will almost certainly do fine. The jobs need to be radically different for it to be worth the morale hit of firing people, and the cost of hiring and onboarding new staff.