It sounds like PostGIS might be a good fit. It gives you a lot of tools for accessing and indexing geometry data, and it can scale to huge sizes. Parsing text

It sounds like PostGIS might be a good fit. It gives you a lot of tools for accessing and indexing geometry data, and it can scale to huge sizes. Parsing text formats is unlikely to be a bottleneck, accessing the data is more likely to be the bottleneck. The correct data structure (schema) and indexes are going to make the biggest difference. If you do complex computations on the data, and it fits in RAM, you'll probably see the best performance if you first load the data into data structures optimized for the computation first, and it's less important how you store the data on disk.