4 ms·

Fibrosis = Scarring. Not good for the heart.

• gnicholas 6y ago
  Thanks! Would love a TLDR from you or another knowledgeable HNer. I couldn’t tell how big a problem this would be for people who are on the keto or IF spectrums.
  • denkmoon 6y ago
    My guess, noting that I am not a doctor or medically trained, merely have a BSc Biology. The study has only been done on rats, which are a good model species but not perfect. The next logical step would be investigating pigs perhaps. The mechanism of heart damage here is probably that the process for maintaining cardiac tissue requires material that is not available on a ketogenic diet, thus unmaintained cardiac tissue is replaced with scar tissue (mostly collagen) The problem with scar tissue in the heart is that it doesn't contribute to fibrilation/pumping blood. Article mentions nothing about intermittent fasting. Again, just guessing.