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I'm not sure what you are refering to, as the end proteins expressed by the ribosome should be the same, even if the syntetic mRNA is optimized for increased ex
by xiphias2 6y ago
I'm not sure what you are refering to, as the end proteins expressed by the ribosome should be the same, even if the syntetic mRNA is optimized for increased expression compared to the non-syntatic one.
At the same time the vaccines can't control which cells get the mRNA delivered as opposed to non-syntetic cells, where the cells are differentiated by their methylation and other epigenetics and gene expression control pathways, which I guess can be problematic for some cell types.
- passivate 6y agoI don't think that is accurate. The spike protein that is being expressed has been modified (2p mutation) to enhance its stability. Proteins have a structure-function relationship and I believe this change in structure was done to inactivate the function of the spike protein, and merely use it as a immunogen. But I was making a different point. Even before you get to the final expression of the protein, there are various steps that need to go smoothly. The mRNA sequence is carefully engineered to dodge the body's various defenses, among other things - and this sort of engineering is not trivial - which is the point I thought you were also making with - "and the hardest part of developing new mRNA vaccines is to research the genetic code to put in it. ". But maybe I misunderstood your original point?