True, but I am not sure that changes things. It's possible that the dose increase doesn't lead to a relevant clinical difference. Ultimately, someone will have

True, but I am not sure that changes things. It's possible that the dose increase doesn't lead to a relevant clinical difference. Ultimately, someone will have to do real world analysis and get conclusions from that. Right now, IMHO, there's better reason to think that a smaller Moderna dose is fine than to trust a single shot Moderna vaccine regiment.