3 ms·

That's fair. I wish we had more properly selective COX-2-only inhibitors, despite the scare about heart issues. I may misunderstand how inhibiting COX 1 would b

That's fair. I wish we had more properly selective COX-2-only inhibitors, despite the scare about heart issues. I may misunderstand how inhibiting COX 1 would balance that out, but I'd be surprised if it does. Many herbs are selective to COX-2, it's like every polyphenol and its mother seems to inhibit it. I looked and you are correct, I did not realize that acetaminophen was not considered an anti-inflammatory. It certainly is antipyretic, and it appears to have some selective COX-2 activity and some potentially mysterious endocannabinoid activity, which I'd personally consider to be anti-inflammatory in one way. That's truly puzzling, I felt I knew that space decently well due to looking into the inflammatory pathways due to MCAS, I stand corrected on the generally public perception of acetaminophen. Hopefully endocannabinoid-class drugs and supplements will enter the mainstream/be developed in a generic, OTC fashion with the easing of perception and laws in cannabinoids. I legitimately wonder how much OTC medication has been held back by analog similarities to the (currently and previously) federally illicit substances in those plants. All good stuff around, I stand corrected and my apologies for any curtness. Have a good one!

ourcat 6y ago
As someone dealing with some painful dental issues during lockdown over the past few months, I have to say, I approve of the endocannabinoid approach.
- tbalsam 6y ago
  I've heard of Ketamine as another non-opioid approach to pain, I don't know how effective it is quite for pain or dental issues. Dental pain is awful. I'm so sorry. I had a hospital-and-hydrocodone-worthy case of oral thrush a few years back and beyond losing the ability to speak...well, at all, for a time, I found myself slamming the counters with my fist so the new pain in my bruised arms took away from the roaring, unending pain in my mouth. I can't imagine having that kind of pain for more than a day or two before being in a dangerous mental state with respect to my own personal safety.
  - ourcat 6y ago
    I wouldn't touch Ketamine. Too many bad side-effects. I've always had a high pain-threshold, but recently I've been 'beside myself' with pain (and a ringing in the ears, driving me mad at night, at times). Cannabinoids have been hugely helpful. Thankfully, I have managed to get an appointment with the dentist next week. But I've had to wait longer than I wanted for it. Years ago, I snapped my leg in half. Tibia and Fibula cleanly snapped. Had Titanium plates put in. That was easier to deal with than dental pain. ;)

ourcat 6y ago

As someone dealing with some painful dental issues during lockdown over the past few months, I have to say, I approve of the endocannabinoid approach.

tbalsam 6y ago
I've heard of Ketamine as another non-opioid approach to pain, I don't know how effective it is quite for pain or dental issues. Dental pain is awful. I'm so sorry. I had a hospital-and-hydrocodone-worthy case of oral thrush a few years back and beyond losing the ability to speak...well, at all, for a time, I found myself slamming the counters with my fist so the new pain in my bruised arms took away from the roaring, unending pain in my mouth. I can't imagine having that kind of pain for more than a day or two before being in a dangerous mental state with respect to my own personal safety.
- ourcat 6y ago
  I wouldn't touch Ketamine. Too many bad side-effects. I've always had a high pain-threshold, but recently I've been 'beside myself' with pain (and a ringing in the ears, driving me mad at night, at times). Cannabinoids have been hugely helpful. Thankfully, I have managed to get an appointment with the dentist next week. But I've had to wait longer than I wanted for it. Years ago, I snapped my leg in half. Tibia and Fibula cleanly snapped. Had Titanium plates put in. That was easier to deal with than dental pain. ;)