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Hi everyone! We’re planning to submit our formal launch on Hacker News in a few weeks, but given this post and all of the discussion around it I thought I would
by dannygrannick 6y ago
Hi everyone! We’re planning to submit our formal launch on Hacker News in a few weeks, but given this post and all of the discussion around it I thought I would share a quick background now!
Bristle (bristlehealth.com) is leveraging the oral microbiome to pioneer oral health testing and care. We use metagenomic sequencing to analyze the oral microbiome from a saliva sample - looking at fungi, bacteria, and viruses - delivering evidence-based insights around oral health.
We are offering an early access program (https://www.bristlehealth.com/pages/early-access https://www.bristlehealth.com/pages/early-access) providing oral microbiome testing and consumer research reports, with literature-backed insights accessed through an interactive web app. We’re charging users $50 and will only bill you when we ship your kit.
If you’re interested in learning more about your oral microbiome, please sign up! We literally launched yesterday and have gotten tons of interest based on exactly what’s being discussed here. We’re letting participants into the program in batches but will be turning kits around rapidly.
If anyone wants to chat more feel free to reach out to info@bristlehealth.com. As I said, we will have a dedicated HN launch with lots more information in the coming weeks, but wanted to share given the interest and that we have this ready to go.
- trash3 6y agoIs there a need to account for circadian rhythms in sampling, do you ask your customers to swab at noon or before bed, or do you just include this info in model training/prediction?
- david_l_lin 6y agoAt the moment, we don't account for circadian rhythms. As we explore some of the insights to the oral microbiome, that's definitely one of the avenues we'd love to dig into. We do ask customers to fill out a relatively detailed health survey, so that we can explore associations between the oral microbiome in health and disease.
- deleted 6y ago[deleted]
- mariushn 6y ago> We do ask customers to fill out a relatively detailed health survey, so that we can explore associations between the oral microbiome in health and disease. So, you're learning from customers these associations, and after a significant number of customers you could offer statistical associations to future customers?
- dannygrannick 6y agoA little bit of both actually - as our user base grows we create a network effect that will spur new statistical associations. We can apply those new findings to new and existing users by updating their report accordingly. You can imagine that even if you took the test once and had (for the sake of simplicity) 1 insight being reported back, you could revisit your profile in 2 years when we have tested 10,000 users and may have 4 new insights that have been added to your report as a result of the new discoveries we've made! TLDR; there are associations reported now, and new ones that will be reported as we grow our user base and data
- dannygrannick 6y agoDavid put it nicely (and more succinctly) in another reply: "In short, there is a network effect with our platform. Each sample we sequence contributes to a database of novel bacteria, viruses, and fungi that we can use to discover new microbes." I would just add that discoveries also apply to new associations that we can include in future reports.
- WoodenChair 6y agoI signed up. $50 to be a guinea pig... Well it will get me to follow where you go, which I think is interesting. Ideally this would already be tested in a clinical trial, so you wouldn't need customers to pay to be your guinea pigs, but it's a low enough sum that I'm willing to do it for the entertainment and educational value to myself. By the way, I was looking for an About page to see the team and couldn't find one (maybe I missed it). I found your link to LinkedIn and saw one of the founders went to the same college as me. That's cool, but I think you should have a "Team" page to give customers confidence. Unless none of you are medical researchers/biologists/doctors/etc. In that case it may actually detract... But surely you at least have some on your advisory board? Good luck and I look forward to trying out the product. I assume part of this might be to eventually sell my microbiome's genetic data, which I'm okay with. You didn't mention on the website (at least I didn't see it) whether the kit also collects cheek cells and such to get my more generalized genetic data. If that's the case, I may just consider it a $50 loss and not participate.
- david_l_lin 6y agoThank you for participating! Co-founder and CSO here. Thanks for the feedback regarding the website, we're in the process of updating the page to improve its layout. We absolutely will not be selling your microbiome data without your consent, and it's something the team and I are quite adamant about. We also will NOT be selling or using any of your personal genetic data without consent. Any analysis and discovery will be on completely de-identified data, and will go toward our goal of improving health care. Thank you for supporting us, and we hope that the insights we provide in the early access may be valuable to you!
- dannygrannick 6y agoRegarding the "about" page - our website is brand new and we're building out more information to coincide with announcements over the coming weeks. One of those is around our advisory board and another is relevant to your comment on clinical trials. Our team has backgrounds in genomics on both the research and commercial side! I worked at Illumina and ONT myself - other co-founders come from companies including Genentech, Twist, etc.
- markdown 6y agoNothing about the mouth biome on HN, ever... and then a day before your launch, this article appears? I feel like I'm being played.
- david_l_lin 6y agoIf only we were that clever
- nmfisher 6y agoThe Economist is always published on Saturday, and is regularly linked on HN. I think more likely they timed their launch to coincide with the Economist article and then someone unrelated just happened to link the article just before their intended date.
- dannygrannick 6y agoWould love to say we thought this far ahead but this was a total coincidence through a text from a friend who is avid on HN
- deleted 6y ago[deleted]
- explore 6y ago1573 results: https://hn.algolia.com/?dateRange=all&page=0&prefix=false&query=microbiome&sort=byPopularity&type=all https://hn.algolia.com/?dateRange=all&page=0&prefix=false&qu...
- lux 6y agoUS only or will you ship to other places too (in Canada myself)?
- david_l_lin 6y agoI'm 90% sure we can do CAN. Sign up for early access through our website: bristlehealth.com, and we'll reach out when your kit is ready!
- kuxv 6y agoWhat about Europe?
- david_l_lin 6y agoI can’t make any immediate guarantees around sending our kit to Europe. However, we do not collect payment until after we ship the kit, so please sign up on our early access page to hold a spot in line. If/when we reach critical mass we may be able to onboard customers in Europe.
- dannygrannick 6y agoDitto to David and we expect to have info on this in the next few days
- dannygrannick 6y agoHi everyone - looking into shipping capabilities. CA should be doable but will have to look into Europe further and will follow up tomorrow! We really appreciate the widespread interest!
- hammock 6y agoI see the ANALYSIS you provide does not use my DNA but I'm unclear- are you collecting my DNA? Are you saving it or storing it, in any form, in either physical or digital form? What assurances do I have that any of the labs or other partners you use won't do this either?
- webmobdev 6y agoFrom another reply - We also will NOT be selling or using any of your personal genetic data without consent. "Genetic data" seems to imply that they do look up your DNA too.
- david_l_lin 6y agoSee Esyir's response. In short, we do NOT look up your DNA, and only look into microbial DNA. In fact, we do a host depletion step to enrich for microbial DNA prior to sequencing, then a following host depletion step prior to microbial mapping. Sequencing will inevitably pick up some signal from the host genome, but at such low levels, we cannot derive meaningful signal from the host DNA. TLDR, we do NOT use host genetic data, but cannot guarantee that none of that data will be stored somewhere in this analysis
- aritmo 6y agoGenetic data is €€€.
- esyir 6y agoThere's no way to get the oral/gun microbiome using shotgun sequencing without also picking up human data along the way. The raw sequence files will contain reads mapping to the human genome, but those are often filtered out in subsequent steps of the data processing.
- david_l_lin 6y agoBristle CSO here. To elaborate on Esyir's reply, through saliva collection, we inevitably will have your DNA in the sample. However, our analysis selectively removes host DNA from the sample, enabling targeted sequencing of the oral microbiome. During the processing of the sample, we may capture some signal from the host genome. Our sequencing, however, captures such a low level of the host genome that we cannot derive any meaningful signal from host genetic data, and actually selectively remove that signal from the analysis to enrich for microbial signals. We keep your saliva sample and its molecular derivatives in physical form completely DEIDENTIFIED such that it cannot be mapped back to YOU without an encrypted key. TLDR, we do NOT use host genetic data, but cannot guarantee that none of that data will be stored somewhere in this analysis. We do not share any identifiable data with anyone. We do not analyze host genetic data.
- devlopr 6y agoWhy the focus on oral? Ubiome had a great product that worked on fecal sample to determine what bacteria's are present in the intestines. Do you see your company expanding into that area?
- david_l_lin 6y agoOur core technology is based around the oral microbiome for a number of key reasons. 1. decades of research have shown causal relationships between the oral microbiome and preventable gum disease. 2. the oral microbiome is much lower in diversity than the fecal microbiome, granting the opportunity for the development of relatively low-cost diagnostics that leverage the microbiome. 3. new and exciting studies have shown correlations between the oral microbiome and a number of systemic health indications, which we hope to continue to uncover with our platform. If you’re interested in learning more, please drop your email at the bottom of our home page at bristlehealth.com to receive our newsletter!
- dannygrannick 6y agoBeautifully said! Also feel free to reach out to info@bristlehealth.com with any specific questions - we’ll get back to you.
- PixelPaul 6y agoThere is no country field and no mention of country limitations. Can I signup from Australian?
- david_l_lin 6y agoApologies for the lack of clarity! I can’t make any immediate guarantees around sending our kit to Australia. However, we do not collect payment until after we ship the kit, so please sign up on our early access page to hold a spot in line. If/when we reach critical mass we may be able to onboard customers from Australia.
- 29athrowaway 6y agoIs this testing service HIPAA compliant? Will you sell my data like 23andme does?
- dannygrannick 6y agoYes and no!
- robbyt 6y agoClassic startup idea validation one-pager. I'm sure you'll get at least a few people signing up, but I don't think this is a good measure if people are really interested. Final price, look of the product, and the ability to market b2c matter much more. 23's success is more based on the execution of their product and marketing. They already have proven for you, there are customers in this space. Now you just need to build something great.
- dannygrannick 6y agoThanks! We're continuing to develop and iterate the final product, and we hope that this program will provide some early user feedback. Current and new users will have their reports updated as we make changes and add new features.
- cnmp 6y agoAh, that explains the microbio* submarines in the past 3 years.